Charles Byrne may refer to:
- Charles Byrne (giant) (1761–1783), also known as "The Irish Giant"
- Charles Alfred Byrne (1848–1909), American journalist and playwright
- Charles C. Byrne (1837–1921), brigadier general in the United States Army
- Charlie Byrne (Australian footballer) (1895–1924), Australian rules footballer
- Charlie Byrne (baseball) (1843–1898), original owner of the Brooklyn Dodgers baseball team
See also
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