C80 may refer to :
- HMS Mauritius (C80), a 1938 British Royal Navy cruiser
- Final Articles Revision Convention, 1946 code
- New Coalinga Municipal Airport FAA LID
- Ruy Lopez chess openings ECO code
- Malignant neoplasm without specification of site ICD-10 code
- Caldwell 80 (Omega Centauri or NGC 5139), a globular cluster in the constellation Centaurus
- C80, carbon-80, a fullerene
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