Bubble boy, boy in the bubble or boy in the plastic bubble may refer to:

  • Severe combined immunodeficiency (also bubble boy disease), a rare genetic disorder characterized by the disturbed development of functional T cells and B cells
  • David Vetter (1971–1984; also "the bubble boy"), American who was a prominent sufferer of severe combined immunodeficiency who was forced to live in a sterile room
  • Ted DeVita (1962–1980), a prominent sufferer of severe aplastic anaemia who was also forced to live in a sterile hospital room

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