At its southern end, in south-western Ville Haute, the N51 meets the N4 at an intersection. From here, it heads northwards, followed by northeastwards, skirting the western edge of Ville Haute. After bending almost a full right angle, it crosses the Alzette river, being carried over Pfaffenthal by the Grand Duchess Charlotte Bridge. On the eastern side, it reaches Kirchberg, where it is known as Avenue John Fitzgerald Kennedy, named after United States PresidentJohn F. Kennedy. The road runs the length of Kirchberg, forming its most important arterial road. It passes several large buildings in Kirchberg, including the Robert Schuman Building, the Philharmonie Luxembourg, d'Coque arena, and the Utopolis Kirchberg cinema. Near the city limits, the N51 meets the A1, which carries traffic eastwards, towards Germany.