America First may refer to:
- America First (policy), a policy and slogan used by U.S. Presidents Woodrow Wilson, Warren G. Harding, and Donald Trump
- America First Committee, a group that opposed entry of the United States into World War II, founded 1940
- America First Party (1944), an isolationist political party
- America First Association, organization established in Minnesota, United States
- America First: A Budget Blueprint to Make America Great Again, 2018 United States federal budget
- "America First" (Homeland), episode of the American television series Homeland
- America First!: Its History, Politics, and Culture, a 1995 book by Bill Kauffman
- America First Credit Union, a credit union in Utah, U.S.
- America First Events Center, a multi-purpose arena in Cedar City, Utah, U.S.
- America First with Sebastian Gorka, a syndicated radio show that debuted in 2019