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Acclimatisation is the process by which the nervous system fails to respond to a stimulus, as a result of the repeated stimulation of a transmission across a synapse. Acclimatisation is believed to occur when the synaptic knob of the presynaptic neurone runs out of vesicles containing neurotransmitters due to overuse over a short period of time. A synapse that has undergone acclimatisation is said to be fatigued. [1]

Acclimatisation is said to be responsible for 'getting used to' background noises and smells.[1]

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  1. ^ a b Hocking, S, et al, (2008), OCR Biology A2, Harlow: Heinemann, pg. 20