A64 or A-64 may refer to:
Roads:
- A64 road (England), a road connecting Leeds and Scarborough
- A64 motorway (France), a road connecting Toulouse and Bayonne
- A64 motorway (Germany), a road connecting the city of Luxembourg and Trier
- A64 highway (Spain), a road connecting the Autovía A-64 junction 367 km and Oviedo
Other uses:
- A further abbreviation of AMD64, a CPU architecture
- An Athlon 64 CPU
- A64 system on a chip designed by Allwinner Technology
- A64 (emulator), a Commodore 64 emulator for the Amiga
- A64, the code for the Benoni Defense in the Encyclopaedia of Chess Openings
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