It is estimated that the [[Single-nucleotide polymorphism|SNP]] M89 appeared 38,700–55,700 years ago, and most likely originated in [[SouthWest Asia]]<ref name=Karafet2008/><ref name=Sengupta2006/> or [[Southeast Asia]]<ref>{{Cite journal|last1=Hallast|first1=Pille|last2=Agdzhoyan|first2=Anastasia|last3=Balanovsky|first3=Oleg|last4=Xue|first4=Yali|last5=Tyler-Smith|first5=Chris|date=2020-07-14|title=A Southeast Asian origin for present-day non-African human Y chromosomes|journal=Human Genetics|volume=140|issue=2|pages=299–307|language=en|doi=10.1007/s00439-020-02204-9|pmid=32666166|pmc=7864842|issn=1432-1203|doi-access=free}}</ref> It has also been suggested by previous research that F-M89 most likely first appeared in the [[Arabian Peninsula]], [[Levant]] or [[North Africa]], about 43,800–56,800 years ago.<ref name="Hammer & Zegura 2002" /> It has also been speculated that the possible location of this lineage's first expansion and rise to prevalence appears to have been in the [[Indian Subcontinent]], or somewhere close to it, and most of the descendant subclades and haplogroups appear to have radiated outward from SouthThe Asia[[Persian Gulf]] and/or neighbouring parts of the [[Middle East]] and [[Southeast Asia]].
Some lineages derived from Haplogroup F-M89 appear to have back-migrated into Africa from [[SouthWest Asia]], during prehistory. For example, subclades of F-M89 were discovered in ancient DNA samples from Sudan, which were associated with both [[Meroë|Meroitic]] and Post-Meroitic [http://khartoumspace.uofk.edu/handle/123456789/6376] burials.
