Prefoldin subunit 1 is a protein that in humans is encoded by the PFDN1 gene.[5][6]

PFDN1
Identifiers
AliasesPFDN1, PDF, PFD1, prefoldin subunit 1
External IDsOMIM: 604897; MGI: 1914449; HomoloGene: 37644; GeneCards: PFDN1; OMA:PFDN1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002622

NM_026027

RefSeq (protein)

NP_002613

NP_080303

Location (UCSC)Chr 5: 140.25 – 140.3 MbChr 18: 36.54 – 36.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113068Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024346Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (Jul 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–73. doi:10.1016/S0092-8674(00)81446-4. PMID 9630229. S2CID 16011829.
  6. ^ a b "Entrez Gene: PFDN1 prefoldin subunit 1".

Further reading

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