Fatty acid-binding protein 2 (FABP2), also known as Intestinal-type fatty acid-binding protein (I-FABP), is a protein that in humans is encoded by the FABP2 gene.[5]

FABP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFABP2, FABPI, I-FABP, fatty acid binding protein 2
External IDsOMIM: 134640; MGI: 95478; HomoloGene: 107; GeneCards: FABP2; OMA:FABP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000134

NM_007980

RefSeq (protein)

NP_000125

NP_032006

Location (UCSC)Chr 4: 119.32 – 119.32 MbChr 3: 122.69 – 122.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

edit

The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells.[5]

Clinical significance

edit

This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance.[5]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145384Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023057Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c "Entrez Gene: FABP2 fatty acid binding protein 2, intestinal".

Further reading

edit