Acyl-CoA dehydrogenase family, member 10 is a protein that in humans is encoded by the ACAD10 gene.[5]

ACAD10
Identifiers
AliasesACAD10, acyl-CoA dehydrogenase family member 10
External IDsOMIM: 611181; MGI: 1919235; HomoloGene: 49825; GeneCards: ACAD10; OMA:ACAD10 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_025247
NM_001136538
NM_001136542

NM_028037

RefSeq (protein)

NP_001130010
NP_079523

NP_082313

Location (UCSC)Chr 12: 111.69 – 111.76 MbChr 5: 121.76 – 121.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Structure

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This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catalytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[5]

Clinical significance

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In Pima people, ACAD10 has been identified as a gene associated with type 2 diabetes, insulin resistance, and impaired lipid metabolism. Specifically, two single nucleotide polymorphisms, rs601663 and rs659964, have been significantly correlated with these symptoms in a large population of both the Pima people and American Indians.[6]

Interactions

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Using affinity capture mass spectrometry, an interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. Using this method, ACAD10 has been shown to interact with P2RY8, NDUFA10, NTRK3, SLC2A12, LPAR4, PTH1R, COLEC10, APP, MAS1, CD79A, BSG, and Ubiquitin C.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111271Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029456Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Acyl-CoA dehydrogenase family, member 10".
  6. ^ Bian L, Hanson RL, Muller YL, Ma L, Kobes S, Knowler WC, Bogardus C, Baier LJ (Jul 2010). "Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians". Diabetologia. 53 (7): 1349–53. doi:10.1007/s00125-010-1695-y. PMC 2947857. PMID 20390405.
  7. ^ "ACAD10 Results Summary". BioGrid. TheTyerslab.com. Retrieved 18 May 2015.
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Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.