Wye can refer to:
- Wye, Kent, a village in Kent, England
- Wye railway station, serving the above village
- Wye, Montana, a town in Missoula County, Montana, USA
- Wye, South Australia, a town in South Australia, Australia
- Wye River (plantation), was the home of William Paca, on the Eastern Shore of Maryland
- Wye River, Victoria, a coastal town in Victoria, Australia
- Wye Road, Strathcona County, Canada
- Wye House, was the home of Edward Lloyd (delegate).
- Wye, a fictional province in Isaac Asimov's Foundation series
- River Wye, the major river, flowing through both Wales and England, rising on Plynlimon to the River Severn
- River Wye, Derbyshire, a river flowing from Axe Edge Moor, Buxton to the River Derwent
- River Wye, Buckinghamshire, a river flowing from the Chiltern Hills in Buckinghamshire to Bourne End where it meets the River Thames
- Wye River, New Zealand, a minor river in the South Island of New Zealand
- Wye River (Maryland), in Maryland, USA
- Wye River (Victoria), Australia
- The letter Y
- Wye (rail), a term used in North American railroading equivalent to an English railway Triangle
- Wye River Memorandum, a series of accords between Israel and the Palestinian Authority agreed at Wye River in Maryland
- Also Wye River Agreements section in the History of Israel page, on the same subject
- A “wye” connection (from “Y”) in electrical engineering, a type of three-phase power connection
- A "wye interchange" (or "Y interchange") between two or more roads or highways, see Full Y interchange
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