The area was first settled right after the American Civil War in the 1870s by the E. M. Wilder family, the namesake for the community. A post office operated in the town from 1874 to 1906. 300 residents lived in the town in the early parts of the 20th century, when Wilderville had two churches, a school, steam gristmills, cottin gins, and a weekly newspaper. However it soon went backfire as the population reached a mere 10 residents in 1930. By 2000, the population had risen to 45 again, but only one store called Wilderville home.