Wetherill is an English language surname, and may refer to:
- Anna Wetherill Olmsted (1888–1961), American curator and museum director
- Charles M. Wetherill, American chemist
- David Wetherill, British table tennis player
- George Wetherill, American physicist
- Louisa Wade Wetherill (1877–1945), American explorer and trader
- Richard Wetherill, American archaeologist
- Roderick Wetherill, American Army general