Weatherspoon is a surname that may refer to these Americans:
In American football edit
- Cephus Weatherspoon (born 1948)
- Chuck Weatherspoon (born 1968)
- Sean Weatherspoon (born 1987)
In basketball edit
- Clarence Weatherspoon (born 1970)
- Nick Weatherspoon (1950–2008)
- Quinndary Weatherspoon (born 1996)
- Teresa Weatherspoon (born 1965)
In music edit
- William Weatherspoon (1936-2005)
See also edit
- Witherspoon (disambiguation)
- Wetherspoons, a British pub chain
- Wotherspoon