Madang1965
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Phenoxymethylpenicillin edit
Hi Madang! Please check your recent edit (see also WP:REF). Since you replaced the reference to Martindale (2002) with BMJ from 1960 (why?), the named links to Martindale in the third paragraph, last sentence and in the AE-Section don't work any more. References should be placed after punctuation, not before (see WP:REFPUNC and WP:PAIC). Please use the Preview in the future before saving a page; you would have noticed the error (in red) in the reference-section. Alfie↑↓© 10:22, 26 April 2011 (UTC)
- Alfie, my aplogies for my editing errors - which were due to inexperience. I will heed your helpful advice. I replaced the Martindale 2002 reference with the two 1960 BMJ papers because Martindale is a secondary reference that provides no evidence to support its assertion that "It (phenoxymethylpenicillin) may be less active against some susceoptible organisms, particularly Gram-negative bacteria." - Martindale, 36th ed, 2009, page 314. On the other hand, the two BMJ papers are peer-reviewed scientific papers that provide direct evidence that phenoxymethylpenicillin has lower activity than benzyl penicillin against Gram-negative bacteria (with descriptions of the methods and results of the experiments). This finding has important practical implications: with oral therapy for bacterial respiratory tract infections, ampicillin or amoxycillin should be used rather than phenoxymethylpenicillin; but with parenteral therapy, benylpenicillin is as effective as ampicillin or amoxycillin (which are more expensive and have more side-effects). This is especially important when treating children in low-income countries who have pneumonia (the commonest cause of death in children) - Google "shann pneumonia children" for references. Frank Shann. Madang1965 (talk) 05:39, 7 August 2011 (UTC)