Other Pages: Desmoglein 1 (Redirect -> Desmoglein); DSG1 (No Data); CDHF4 (No Data); Cdhf4 (No Data); DG1 (No Data); Dg1 (No Data); DSG (DisAmbig); Dsg (No Data); Desmoglein (Protein Template);
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:30:16 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CRYGD_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1h4a.
| PDB = {{PDB2|1h4a}}, {{PDB2|1hk0}}, {{PDB2|2g98}}
| Name = Crystallin, gamma D
| HGNCid = 2411
| Symbol = CRYGD
| AltSymbols =; CACA; CCA3; CRYG4; cry-g-D
| OMIM = 123690
| ECnumber =
| Homologene = 36213
| MGIid = 88524
| GeneAtlas_image1 = PBB_GE_CRYGD_207532_at_tn.png
| Function = {{GNF_GO|id=GO:0005212 |text = structural constituent of eye lens}}
| Component =
| Process = {{GNF_GO|id=GO:0001654 |text = eye development}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1421
| Hs_Ensembl = ENSG00000118231
| Hs_RefseqProtein = NP_008822
| Hs_RefseqmRNA = NM_006891
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 208694577
| Hs_GenLoc_end = 208697458
| Hs_Uniprot = P07320
| Mm_EntrezGene = 12967
| Mm_Ensembl = ENSMUSG00000067299
| Mm_RefseqmRNA = NM_007776
| Mm_RefseqProtein = NP_031802
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 64996115
| Mm_GenLoc_end = 64997697
| Mm_Uniprot = Q6PGI0
}}
}}
'''Crystallin, gamma D''', also known as '''CRYGD''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.<ref>{{cite web | title = Entrez Gene: CRYGD crystallin, gamma D| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1421| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Graw J |title=The crystallins: genes, proteins and diseases. |journal=Biol. Chem. |volume=378 |issue= 11 |pages= 1331-48 |year= 1998 |pmid= 9426193 |doi= }}
*{{cite journal | author=Slingsby C, Clout NJ |title=Structure of the crystallins. |journal=Eye (London, England) |volume=13 ( Pt 3b) |issue= |pages= 395-402 |year= 2000 |pmid= 10627816 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on DAZ1... {November 9, 2007 4:31:06 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:33:30 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Deleted in azoospermia 1
| HGNCid = 2682
| Symbol = DAZ1
| AltSymbols =; DAZ; SPGY; DAZ1; pDP1680; pDP1681
| OMIM = 400003
| ECnumber =
| Homologene = 88435
| MGIid =
| GeneAtlas_image1 = PBB_GE_DAZ1_207912_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_DAZ1_208281_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_DAZ1_208282_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008494 |text = translation activator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0007338 |text = single fertilization}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0045948 |text = positive regulation of translational initiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1617
| Hs_Ensembl = ENSG00000205916
| Hs_RefseqProtein = NP_004072
| Hs_RefseqmRNA = NM_004081
| Hs_GenLoc_db =
| Hs_GenLoc_chr = Y
| Hs_GenLoc_start = 25389368
| Hs_GenLoc_end = 25462575
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Deleted in azoospermia 1''', also known as '''DAZ1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains three copies of the 10.8 kb repeat. However, no transcripts containing three copies of the RRM domain have been described; thus the RefSeq for this gene contains only two RRM domains.<ref>{{cite web | title = Entrez Gene: DAZ1 deleted in azoospermia 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1617| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Foresta C, Ferlin A, Moro E, ''et al.'' |title=[Microdeletion of chromosome Y in male infertility: role of the DAZ gene] |journal=Ann. Ital. Med. Int. |volume=16 |issue= 2 |pages= 82-92 |year= 2002 |pmid= 11688365 |doi= }}
*{{cite journal | author=Fox MS, Reijo Pera RA |title=Male infertility, genetic analysis of the DAZ genes on the human Y chromosome and genetic analysis of DNA repair. |journal=Mol. Cell. Endocrinol. |volume=184 |issue= 1-2 |pages= 41-9 |year= 2002 |pmid= 11694340 |doi= }}
*{{cite journal | author=Vogt PH, Fernandes S |title=Polymorphic DAZ gene family in polymorphic structure of AZFc locus: Artwork or functional for human spermatogenesis? |journal=APMIS |volume=111 |issue= 1 |pages= 115-26; discussion 126-7 |year= 2003 |pmid= 12752250 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on DVL1... {November 9, 2007 4:39:39 PM PST}
UPLOAD: Added new Image to wiki: {November 9, 2007 4:39:55 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:40:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_DVL1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fsh.
| PDB = {{PDB2|1fsh}}, {{PDB2|1mc7}}
| Name = Dishevelled, dsh homolog 1 (Drosophila)
| HGNCid = 3084
| Symbol = DVL1
| AltSymbols =; DVL; MGC54245
| OMIM = 601365
| ECnumber =
| Homologene = 20926
| MGIid = 94941
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0007222 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1855
| Hs_Ensembl =
| Hs_RefseqProtein = NP_004412
| Hs_RefseqmRNA = NM_004421
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 13542
| Mm_Ensembl = ENSMUSG00000029071
| Mm_RefseqmRNA = NM_010091
| Mm_RefseqProtein = NP_034221
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 154691212
| Mm_GenLoc_end = 154703103
| Mm_Uniprot = Q3TRW4
}}
}}
'''Dishevelled, dsh homolog 1 (Drosophila)''', also known as '''DVL1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Three transcript variants encoding three different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: DVL1 dishevelled, dsh homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1855| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wharton KA |title=Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. |journal=Dev. Biol. |volume=253 |issue= 1 |pages= 1-17 |year= 2003 |pmid= 12490194 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on ESRRA... {November 9, 2007 4:40:07 PM PST}
UPLOAD: Added new Image to wiki: {November 9, 2007 4:42:22 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:42:44 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ESRRA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1lo1.
| PDB = {{PDB2|1lo1}}, {{PDB2|1xb7}}
| Name = Estrogen-related receptor alpha
| HGNCid = 3471
| Symbol = ESRRA
| AltSymbols =; ERR1; ERRa; ERRalpha; ESRL1; NR3B1
| OMIM = 601998
| ECnumber =
| Homologene = 20941
| MGIid = 1346831
| GeneAtlas_image1 = PBB_GE_ESRRA_1487_at_tn.png
| GeneAtlas_image2 = PBB_GE_ESRRA_203193_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0005496 |text = steroid binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016439 |text = tRNA-pseudouridine synthase activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2101
| Hs_Ensembl = ENSG00000173153
| Hs_RefseqProtein = NP_004442
| Hs_RefseqmRNA = NM_004451
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 63829616
| Hs_GenLoc_end = 63840786
| Hs_Uniprot = P11474
| Mm_EntrezGene = 26379
| Mm_Ensembl = ENSMUSG00000024955
| Mm_RefseqmRNA = NM_007953
| Mm_RefseqProtein = NP_031979
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 6978022
| Mm_GenLoc_end = 6988862
| Mm_Uniprot = Q3U110
}}
}}
'''Estrogen-related receptor alpha''', also known as '''ESRRA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1.<ref>{{cite web | title = Entrez Gene: ESRRA estrogen-related receptor alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2101| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:44:14 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FKBP4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1n1a.
| PDB = {{PDB2|1n1a}}, {{PDB2|1p5q}}, {{PDB2|1q1c}}, {{PDB2|1qz2}}, {{PDB2|1rot}}, {{PDB2|1rou}}
| Name = FK506 binding protein 4, 59kDa
| HGNCid = 3720
| Symbol = FKBP4
| AltSymbols =; PPIase; FKBP52; FKBP59; HBI; Hsp56; p52
| OMIM = 600611
| ECnumber =
| Homologene = 36085
| MGIid = 95543
| GeneAtlas_image1 = PBB_GE_FKBP4_200895_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_FKBP4_200894_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003755 |text = peptidyl-prolyl cis-trans isomerase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}} {{GNF_GO|id=GO:0005528 |text = FK506 binding}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}} {{GNF_GO|id=GO:0030674 |text = protein binding, bridging}} {{GNF_GO|id=GO:0031072 |text = heat shock protein binding}} {{GNF_GO|id=GO:0035259 |text = glucocorticoid receptor binding}} {{GNF_GO|id=GO:0051219 |text = phosphoprotein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006463 |text = steroid hormone receptor complex assembly}} {{GNF_GO|id=GO:0007566 |text = embryo implantation}} {{GNF_GO|id=GO:0031503 |text = protein complex localization}} {{GNF_GO|id=GO:0046661 |text = male sex differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2288
| Hs_Ensembl = ENSG00000004478
| Hs_RefseqProtein = NP_002005
| Hs_RefseqmRNA = NM_002014
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 2774414
| Hs_GenLoc_end = 2783381
| Hs_Uniprot = Q02790
| Mm_EntrezGene = 14228
| Mm_Ensembl = ENSMUSG00000030357
| Mm_RefseqmRNA = NM_010219
| Mm_RefseqProtein = NP_034349
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 128395157
| Mm_GenLoc_end = 128404275
| Mm_Uniprot = Q8CBS1
}}
}}
'''FK506 binding protein 4, 59kDa''', also known as '''FKBP4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. This gene has been found to have multiple polyadenylation sites.<ref>{{cite web | title = Entrez Gene: FKBP4 FK506 binding protein 4, 59kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2288| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Schiene-Fischer C, Yu C |title=Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases. |journal=FEBS Lett. |volume=495 |issue= 1-2 |pages= 1-6 |year= 2001 |pmid= 11322937 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on LAMB1... {November 9, 2007 4:48:19 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:49:18 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Laminin, beta 1
| HGNCid = 6486
| Symbol = LAMB1
| AltSymbols =; CLM; MGC142015
| OMIM = 150240
| ECnumber =
| Homologene = 1722
| MGIid = 96743
| GeneAtlas_image1 = PBB_GE_LAMB1_201505_at_tn.png
| GeneAtlas_image2 = PBB_GE_LAMB1_211651_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0019899 |text = enzyme binding}}
| Component = {{GNF_GO|id=GO:0005604 |text = basement membrane}} {{GNF_GO|id=GO:0005606 |text = laminin-1 complex}} {{GNF_GO|id=GO:0005607 |text = laminin-2 complex}} {{GNF_GO|id=GO:0043257 |text = laminin-8 complex}} {{GNF_GO|id=GO:0043259 |text = laminin-10 complex}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007566 |text = embryo implantation}} {{GNF_GO|id=GO:0030335 |text = positive regulation of cell migration}} {{GNF_GO|id=GO:0031175 |text = neurite development}} {{GNF_GO|id=GO:0042476 |text = odontogenesis}} {{GNF_GO|id=GO:0050679 |text = positive regulation of epithelial cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3912
| Hs_Ensembl = ENSG00000091136
| Hs_RefseqProtein = NP_002282
| Hs_RefseqmRNA = NM_002291
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 107351499
| Hs_GenLoc_end = 107431040
| Hs_Uniprot = P07942
| Mm_EntrezGene = 16777
| Mm_Ensembl = ENSMUSG00000002900
| Mm_RefseqmRNA = NM_008482
| Mm_RefseqProtein = NP_032508
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 31851443
| Mm_GenLoc_end = 31915700
| Mm_Uniprot = Q0V927
}}
}}
'''Laminin, beta 1''', also known as '''LAMB1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.<ref>{{cite web | title = Entrez Gene: LAMB1 laminin, beta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3912| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ljubimova JY, Fujita M, Khazenzon NM, ''et al.'' |title=Changes in laminin isoforms associated with brain tumor invasion and angiogenesis. |journal=Front. Biosci. |volume=11 |issue= |pages= 81-8 |year= 2006 |pmid= 16146715 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on LBP... {November 9, 2007 4:49:18 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:50:16 PM PST}
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{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Lipopolysaccharide binding protein
| HGNCid = 6517
| Symbol = LBP
| AltSymbols =; MGC22233
| OMIM = 151990
| ECnumber =
| Homologene = 3055
| MGIid = 1098776
| GeneAtlas_image1 = PBB_GE_LBP_214461_at_tn.png
| GeneAtlas_image2 = PBB_GE_LBP_211652_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001530 |text = lipopolysaccharide binding}} {{GNF_GO|id=GO:0008289 |text = lipid binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006869 |text = lipid transport}} {{GNF_GO|id=GO:0006953 |text = acute-phase response}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3929
| Hs_Ensembl = ENSG00000129988
| Hs_RefseqProtein = NP_004130
| Hs_RefseqmRNA = NM_004139
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 36408299
| Hs_GenLoc_end = 36439067
| Hs_Uniprot = P18428
| Mm_EntrezGene = 16803
| Mm_Ensembl = ENSMUSG00000016024
| Mm_RefseqmRNA = NM_008489
| Mm_RefseqProtein = NP_032515
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 157997986
| Mm_GenLoc_end = 158023737
| Mm_Uniprot = Q61805
}}
}}
'''Lipopolysaccharide binding protein''', also known as '''LBP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.<ref>{{cite web | title = Entrez Gene: LBP lipopolysaccharide binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3929| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}