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| Clinical data | |
|---|---|
| Other names | N-(3-Methyl-5-sulfamoyl-3H-1,3,4-thiadiazol-2-ylidene) ethanamide |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a601233 |
| Routes of administration | By mouth |
| Drug class | Carbonic anhydrase inhibitor[1] |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Protein binding | ~55% |
| Onset of action | Within 4 hrs[1] |
| Elimination half-life | ~14 hours |
| Duration of action | Up to 18 hrs[1] |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C5H8N4O3S2 |
| Molar mass | 236.26 g·mol−1 |
| 3D model (JSmol) | |
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Methazolamide, sold under the brand name Neptazane among, is a medication used to treat increased intraocular pressure (IOP) including in glaucoma.[1] It is taken by mouth.[1] Effects begin within 4 hours and last for up to 18 hours.[1]
Common side effects include numbness, hearing problems, tiredness, nausea, diarrhea, and sleepiness.[1] Other side effects may include Stevens-Johnson syndrome.[1] It is an carbonic anhydrase inhibitor which decreases the production of aqueous humor.[1]
Methazolamide was approved for medical use in the United States in 1950s.[1][2] In the United States 60 tablets of 50 mg costs about 125 USD as of 2021.[3]
References edit
- ^ a b c d e f g h i j k l "Methazolamide Monograph for Professionals". Drugs.com. Archived from the original on 7 May 2021. Retrieved 17 November 2021.
- ^ Supuran, Claudiu T.; Nocentini, Alessio (17 July 2019). Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target. Academic Press. p. 271. ISBN 978-0-12-816745-8. Archived from the original on 17 November 2021. Retrieved 17 November 2021.
- ^ "Methazolamide Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 5 November 2016. Retrieved 17 November 2021.