 | |
 Formoterol (top), (R,R)-(−)-formoterol (center) and (S,S)-(+)-formoterol (bottom) | |
| Clinical data | |
|---|---|
| Trade names | Oxeze, Perforomist, others |
| AHFS/Drugs.com | Monograph |
| License data | |
| Pregnancy category |
|
| Routes of administration | Inhalation (capsules for oral inhalation, DPI, MDI) |
| Drug class | LABA[1] |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Protein binding | 61% to 64% |
| Metabolism | Liver demethylation and glucuronidation (CYP2D6, CYP2C19, CYP2C9 and CYP2A6 involved) |
| Onset of action | Up to 3 hr for max. effect[1] |
| Elimination half-life | 10 h |
| Duration of action | 12 h[1] |
| Excretion | Kidney and fecal |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C19H24N2O4 |
| Molar mass | 344.411 g·mol−1 |
| 3D model (JSmol) | |
| Chirality | Racemic mixture |
| |
| |
| (verify) | |
Formoterol, also known as eformoterol, is a used in the long term management of asthma and chronic obstructive pulmonary disease (COPD).[3] It is used by breathing it into the lungs.[3] Full effects take about 2 hours and last about 12 h.[1]
Common side effects include dry mouth, trouble sleeping, nausea, and throat inflammation.[1] Other side effects may include bronchospasm, anaphylaxis, and QT prolongation.[1] In asthma, it may increase the risk of death if used without an inhaled steroid.[1] Use in pregnancy is of unclear safety.[1] It is a long-acting β2 agonist (LABA).[1]
Formoterol was patented in 1972 and came into medical use in 1998.[4] It is available as a generic medication.[5] In the United Kingdom it costs the NHS about £12 per month as of 2021.[3] In the United States this amount costs about 285 USD.[5] It is also available in combination as budesonide/formoterol and mometasone/formoterol.[3][1]
References edit
- ^ a b c d e f g h i j k "Formoterol Monograph for Professionals". Drugs.com. Archived from the original on 28 November 2021. Retrieved 13 December 2021.
- ^ "Archive copy" (PDF). Archived (PDF) from the original on 2021-10-31. Retrieved 2021-07-12.
{{cite web}}: CS1 maint: archived copy as title (link) - ^ a b c d e BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 267. ISBN 978-0857114105.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 543. ISBN 9783527607495. Archived from the original on 2021-07-24. Retrieved 2021-07-12.
- ^ a b "Formoterol Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 13 December 2021.