User:Mr. Ibrahem/Dobutamine

Mr. Ibrahem/Dobutamine
Clinical data
Trade names	Dobutrex, Inotrex, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682861
License data	US DailyMed: Dobutamine;
Pregnancy; category	AU: B2; ;
Routes of; administration	Intravenous, intraosseous
Drug class	β1-agonist
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Onset of action	Within 2 min
Elimination half-life	2 minutes
Identifiers
	IUPAC name (RS)-4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol;
Chemical and physical data
Formula	C18H23NO3
Molar mass	301.386 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES Oc1ccc(cc1O)CCNC(C)CCc2ccc(O)cc2;
	InChI InChI=1S/C18H23NO3/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15/h4-9,12-13,19-22H,2-3,10-11H2,1H3 ; Key:JRWZLRBJNMZMFE-UHFFFAOYSA-N ;
	(verify)

Dobutamine is a medication used in the treatment of cardiogenic shock and severe heart failure.^[2]^[4] It may also be used in certain types of cardiac stress tests.^[2] It is given by injection into a vein or intraosseous as a continuous infusion.^[2] The amount of medication needs to be adjusted to the desired effect.^[2] Onset of effects is generally seen within 2 minutes.^[2]

Common side effects include a fast heart rate, an irregular heart beat, and inflammation at the site of injection.^[2]^[5] Use is not recommended in those with idiopathic hypertrophic subaortic stenosis.^[2] It primarily works by direct stimulation of β₁ receptors, which increases the strength of the heart's contractions.^[2] Generally it has little effect on a person's heart rate.^[2]

Dobutamine was approved for medical use in the United States in 1978.^[2] It is available as a generic medication.^[5] In the United Kingdom as of 2018 it costs the NHS about 2 pounds per vial.^[5] It was initially made from isoproterenol.^[4]

References edit

^ ^a ^b "Dobutamine (Dobutrex) Use During Pregnancy". Drugs.com. 18 March 2020. Retrieved 17 May 2020.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l "Dobutamine Hydrochloride Monograph for Professionals". Drugs.com. AHFS. Retrieved 11 January 2019.
^ Cite error: The named reference WHO2020DDD was invoked but never defined (see the help page).
^ ^a ^b Wilson, William C.; Grande, Christopher M.; Hoyt, David B. (2007). Trauma: Critical Care. CRC Press. p. 302. ISBN 9781420016840.
^ ^a ^b ^c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 220–221. ISBN 9780857113382.

en:Dobutamine

[Drugs.com_pregnancy-1] "Dobutamine (Dobutrex) Use During Pregnancy". Drugs.com. 18 March 2020. Retrieved 17 May 2020.

[AHFS2019-2] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l "Dobutamine Hydrochloride Monograph for Professionals". Drugs.com. AHFS. Retrieved 11 January 2019.

[WHO2020DDD-3] Cite error: The named reference WHO2020DDD was invoked but never defined (see the help page).

[Wil2007-4] Wilson, William C.; Grande, Christopher M.; Hoyt, David B. (2007). Trauma: Critical Care. CRC Press. p. 302. ISBN 9781420016840.

[BNF76-5] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 220–221. ISBN 9780857113382.

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