User:Mr. Ibrahem/Diflunisal

Mr. Ibrahem/Diflunisal
Clinical data
Trade names	Dolobid, others
AHFS/Drugs.com	Monograph
MedlinePlus	a684037
Pregnancy; category	AU: C; ;
Routes of; administration	By mouth
Drug class	NSAID
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	80-90%
Protein binding	>99%
Metabolism	Liver
Onset of action	Within an hour
Elimination half-life	8 to 12 hours
Duration of action	Up to 12 hours
Excretion	Kidney
Identifiers
	IUPAC name 2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid;
Chemical and physical data
Formula	C13H8F2O3
Molar mass	250.201 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)c1cc(ccc1O)c2ccc(F)cc2F;
	InChI InChI=1S/C13H8F2O3/c14-8-2-3-9(11(15)6-8)7-1-4-12(16)10(5-7)13(17)18/h1-6,16H,(H,17,18) ; Key:HUPFGZXOMWLGNK-UHFFFAOYSA-N ;
	(verify)

Diflunisal, sold under the brand name Dolobid among others, is an nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, fever, and inflammation.^[1]^[2] Specifically it is used for mild to moderate pain.^[1] Onset is within an hour with duration of effects of up to 12 hours.^[1]^[2] It is taken by mouth.^[1]

Common side effects include nausea, upset stomach, tiredness, ringing in the ears, and rash.^[1] Severe side effects may include heart problems, high blood pressure, swelling, kidney problems, and gastrointestinal bleeding.^[1] Use in the later part of pregnancy may harm the baby.^[1] It is a derivative of salicylic acid.^[1]

Diflunisal was developed by Merck Sharp & Dohme in 1971, and came into medical use in the United States in 1982.^[3] It is available as a generic medication.^[4] In the United States 60 tabs of 500 mg costs about 33 USD as of 2021.^[5]

References edit

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l "Diflunisal Monograph for Professionals". Drugs.com. Archived from the original on 8 August 2020. Retrieved 16 July 2021.
^ ^a ^b ^c Dowd, Frank J.; Yagiela, John A.; Johnson, Bart; Mariotti, Angelo; Neidle, Enid A. (19 March 2010). Pharmacology and Therapeutics for Dentistry - E-Book. Elsevier Health Sciences. p. 337. ISBN 978-0-323-07824-5. Archived from the original on 28 August 2021. Retrieved 16 July 2021.
^ Adams SS (1999). "Ibuprofen, the propionics and NSAIDs: personal reflections over four decades". Inflammopharmacology. 7 (3): 191–7. doi:10.1007/s10787-999-0002-3. PMID 17638090. S2CID 11074565.
^ Nitzki-George, Diane (September 2003). Generic Alternatives to Prescription Drugs. Basic Health Publications, Inc. p. 343. ISBN 978-1-59120-098-7. Archived from the original on 2021-08-28. Retrieved 2021-07-16.
^ "Diflunisal Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 3 November 2016. Retrieved 16 July 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l "Diflunisal Monograph for Professionals". Drugs.com. Archived from the original on 8 August 2020. Retrieved 16 July 2021.

[Dow2010-2] Dowd, Frank J.; Yagiela, John A.; Johnson, Bart; Mariotti, Angelo; Neidle, Enid A. (19 March 2010). Pharmacology and Therapeutics for Dentistry - E-Book. Elsevier Health Sciences. p. 337. ISBN 978-0-323-07824-5. Archived from the original on 28 August 2021. Retrieved 16 July 2021.

[3] Adams SS (1999). "Ibuprofen, the propionics and NSAIDs: personal reflections over four decades". Inflammopharmacology. 7 (3): 191–7. doi:10.1007/s10787-999-0002-3. PMID 17638090. S2CID 11074565.

[4] Nitzki-George, Diane (September 2003). Generic Alternatives to Prescription Drugs. Basic Health Publications, Inc. p. 343. ISBN 978-1-59120-098-7. Archived from the original on 2021-08-28. Retrieved 2021-07-16.

[GX2021-5] "Diflunisal Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 3 November 2016. Retrieved 16 July 2021.

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