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User:Mr. Ibrahem/Cyproheptadine

< User:Mr. Ibrahem
Mr. Ibrahem/Cyproheptadine
Clinical data
Pronunciation(/ˌsaɪproʊˈhɛptədiːn/[1]
Trade namesPeriactin, others
AHFS/Drugs.comMonograph
MedlinePlusa682541
License data
Pregnancy
category
  • AU: A
Routes of
administration		By mouth
Drug classFirst-generation antihistamine[2][3]
Legal status
Legal status
Pharmacokinetic data
Protein binding96 to 99%
MetabolismLiver[5][6] Mostly CYP3A4 mediated.
Elimination half-life8.6 hours[4]
ExcretionFaecal (2-20%; 34% of this as unchanged drug) and renal (40%; none as unchanged drug)[5][6]
Identifiers
  • 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine
Chemical and physical data
FormulaC21H21N
Molar mass287.406 g·mol−1
3D model (JSmol)
  • c43\C(=C1/CCN(C)CC1)c2ccccc2\C=C/c3cccc4
  • InChI=1S/C21H21N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21/h2-11H,12-15H2,1H3 checkY
  • Key:JJCFRYNCJDLXIK-UHFFFAOYSA-N checkY
  (verify)

Cyproheptadine, sold under the brand name Periactin among others, is a first-generation antihistamine primarily used to treat allergies.[2][3] This may include itchiness, hay fever, and hives.[3] It is taken by mouth.[2]

Common side effects include sleepiness, dizziness, agitation, and poor coordination.[2] Other side effects may include swelling, problems urinating, and increased weight.[3] There is no evidence of harm with use during pregnancy, however such use has not been well studied.[7] Care should be taken in those at risk of glaucoma.[3]

Cyproheptadine was patented in 1959 and came into medical use in 1961.[8] It is available as a generic medication.[9] In the United Kingdom 30 tablets of 4 mg costs the NHS about 6 pounds in 2020.[3] This amount in the United States costs about 10 USD.[9]

References edit

  1. ^ "Cyproheptadine". Dictionary.com Unabridged (Online). n.d.
  2. ^ a b c d e f "Cyproheptadine Hydrochloride Monograph for Professionals". Drugs.com. Archived from the original on 11 December 2018. Retrieved 19 November 2020.
  3. ^ a b c d e f g BNF 79. London: Pharmaceutical Press. March 2020. p. 292. ISBN 978-0857113658.
  4. ^ Gunja N, Collins M, Graudins A (2004). "A comparison of the pharmacokinetics of oral and sublingual cyproheptadine". Journal of Toxicology. Clinical Toxicology. 42 (1): 79–83. doi:10.1081/clt-120028749. PMID 15083941. S2CID 20196551.
  5. ^ a b "CYPROHEPTADINE HYDROCHLORIDE tablet [Boscogen, Inc.]" (PDF). DailyMed. Boscogen, Inc. November 2010. Archived from the original on 4 July 2013. Retrieved 26 October 2013.
  6. ^ a b "PRODUCT INFORMATION PERIACTIN® (cyproheptadine hydrochloride)" (PDF). Aspen Pharmacare Australia. Aspen Pharmacare Australia Pty Ltd. 17 November 2011. Archived from the original (PDF) on 29 October 2013. Retrieved 26 October 2013.
  7. ^ "Cyproheptadine (Periactin) Use During Pregnancy". Drugs.com. Archived from the original on 25 November 2020. Retrieved 19 November 2020.
  8. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 547. ISBN 9783527607495. Archived from the original on 2021-08-29. Retrieved 2020-09-19.
  9. ^ a b "Cyproheptadine". Archived from the original on 11 November 2016. Retrieved 19 November 2020.
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