Clinical data | |
---|---|
Trade names | Flexeril, Amrix, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682514 |
Pregnancy category |
|
Routes of administration | By mouth |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Bioavailability | 33–55%[2][3] |
Protein binding | 93% |
Metabolism | Major: CYP3A4, CYP1A2; Minor: CYP2D6, N-demethylation[5] |
Metabolites | Norcyclobenzaprine |
Elimination half-life | 32 hours (range 8–37 hours)[4] |
Excretion | Kidney |
Identifiers | |
| |
Chemical and physical data | |
Formula | C20H21N |
Molar mass | 275.395 g·mol−1 |
3D model (JSmol) | |
| |
| |
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Cyclobenzaprine, sold under the brand name Flexeril among others, is a medication used for muscle spasms from musculoskeletal conditions of sudden onset.[6] It is not useful in cerebral palsy.[6] It is taken by mouth.[6] Use is not recommended for more than a few weeks.[6]
Common side effects include headache, feeling tired, dizziness, and dry mouth.[6] Serious side effects may include an irregular heart beat.[6] There is no evidence of harm in pregnancy, but it has not been well studied in this population.[6] It should not be used with an MAO inhibitor.[6] How it works is unclear.[6]
Cyclobenzaprine was approved for medical use in the United States in 1977.[6] It is available as a generic medication.[6] In the United States, the wholesale cost per dose is less than US$0.05 as of 2018.[8] In 2017, it was the 43rd most commonly prescribed medication in the United States, with more than 17 million prescriptions.[9][10] It was not available in the United Kingdom as of 2012.[11]
References edit
- ^ "Cyclobenzaprine Use During Pregnancy". Drugs.com. Archived from the original on 2 June 2019. Retrieved 8 January 2020.
- ^ Micromedex® 2010 – DRUGDEX Evaluations (Cyclobenzaprine Hydrochloride)
- ^ "Cyclobenzaprine Hydrochloride Tablets USP Revised: April 2005 Rx only". nih.gov. Archived from the original on 21 April 2016. Retrieved 1 October 2016.
- ^ Teva Pharmaceuticals USA, Inc (May 2016). "AMR40470 (Amrix) Prescribing Information" (PDF). Archived (PDF) from the original on 22 December 2016. Retrieved 2 February 2017.
- ^ Teva Pharmaceuticals USA, Inc (May 2016). "AMR40470 (Amrix) Prescribing Information" (PDF). Archived (PDF) from the original on 22 December 2016. Retrieved 2 February 2017.
- ^ a b c d e f g h i j k l m "Cyclobenzaprine Monograph for Professionals". Drugs.com. AHFS. Archived from the original on 23 December 2018. Retrieved 22 December 2018.
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 26 September 2020. Retrieved 9 September 2020.
- ^ "NADAC as of 2018-12-19". Centers for Medicare and Medicaid Services. Archived from the original on 19 December 2018. Retrieved 22 December 2018.
- ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
- ^ "Cyclobenzaprine - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 11 April 2020.
- ^ "Fibromyalgia, psychiatric comorbidity, and the somatosensory cortex". British Journal of Medical Practitioners. 5 (2): a522. 2012. Archived from the original on 23 December 2018. Retrieved 22 December 2018.