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| Clinical data | |
|---|---|
| Pronunciation | /əˌtɔːrvəˈstætən/ |
| Trade names | Lipitor, Sortis, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a600045 |
| License data |
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| Pregnancy category | |
| Routes of administration | By mouth |
| Drug class | Statin |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | 12% |
| Metabolism | Liver (CYP3A4) |
| Elimination half-life | 14 hours |
| Excretion | Bile |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C33H35FN2O5 |
| Molar mass | 558.64 g·mol−1 |
| 3D model (JSmol) | |
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| (verify) | |
Atorvastatin, sold under the brand name Lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipid levels.[2] For the prevention of cardiovascular disease, statins are a first-line treatment.[2] It is taken by mouth.[2]
Common side effects include joint pain, diarrhea, heartburn, nausea, and muscle pains.[2] Serious side effects may include rhabdomyolysis, liver problems, and diabetes.[2] Use during pregnancy may harm the baby.[2] Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in the liver that plays a role in producing cholesterol.[2]
Atorvastatin was patented in 1986, and approved for medical use in the United States in 1996.[2][4] It is available as a generic medication and is relatively inexpensive.[2][5] In 2018, it was the most prescribed medication in the United States, with more than 112 million prescriptions.[6]
References edit
- ^ a b c "Atorvastatin (Lipitor) Use During Pregnancy". Drugs.com. 3 February 2020. Archived from the original on 4 December 2019. Retrieved 26 February 2020.
- ^ a b c d e f g h i j k "Atorvastatin Calcium Monograph for Professionals". Drugs.com. AHFS. Archived from the original on 25 October 2010. Retrieved 23 December 2018.
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 7 August 2020. Retrieved 9 September 2020.
- ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 473. ISBN 9783527607495. Archived from the original on 16 May 2021. Retrieved 10 May 2020.
- ^ Hitchings, Andrew; Lonsdale, Dagan; Burrage, Daniel; Baker, Emma (2019). The Top 100 Drugs: Clinical Pharmacology and Practical Prescribing (2nd ed.). Elsevier. p. 205. ISBN 978-0-7020-7442-4. Archived from the original on 25 March 2021. Retrieved 9 January 2021.
- ^ "The Top 300 of 2021". clincalc.com. Archived from the original on 12 February 2021. Retrieved 20 November 2020.