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User:Mr. Ibrahem/Almotriptan

< User:Mr. Ibrahem
Mr. Ibrahem/Almotriptan
Ball-and-stick model of the almotriptan molecule
Clinical data
Trade namesAxert
Other namesAlmotriptan hydrogen malate[1]
AHFS/Drugs.comMonograph
MedlinePlusa603028
License data
Routes of
administration		By mouth
Drug classTriptan[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability70%
Protein binding35%
MetabolismLiver
Elimination half-life3–4 hours
Identifiers
  • N,N-dimethyl-2- [5-(pyrrolidin-1-ylsulfonylmethyl)- 1H-indol-3-yl]-ethanamine
Chemical and physical data
FormulaC17H25N3O2S
Molar mass335.47 g·mol−1
3D model (JSmol)
  • CN(C)CCc2c[nH]c3ccc(CS(=O)(=O)N1CCCC1)cc23
  • InChI=1S/C17H25N3O2S/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3 checkY
  • Key:WKEMJKQOLOHJLZ-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Almotriptan, sold under the brand name Axert among others, is a medication used to treat migraine headaches.[1] It may be used in people over the age of 11.[6] There is a lack of evidence for cluster headaches.[6] It is taken by mouth.[1]

Common side effects include nausea, dry mouth, sleepiness, and numbness.[5] Other side effects may include heart problems, stroke, Raynaud syndrome, serotonin syndrome, and medication overuse headaches.[5] Use in pregnancy may harm the baby.[5] It is a triptan.[1]

Almotriptan was patented in 1992 and approved for medical use in 2000.[7] It is available as a generic medication.[1] In the United Kingdom it costs the NHS about £2.80 a dose as of 2021.[1] This amount in the United States is about 9 USD.[8]

References edit

  1. ^ a b c d e f g h i BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 500. ISBN 978-0857114105.
  2. ^ "Almotriptan tablet, film coated". DailyMed. Archived from the original on 24 March 2021. Retrieved 17 February 2021.
  3. ^ "Axert- almotriptan malate tablet, coated". DailyMed. Archived from the original on 23 March 2021. Retrieved 17 February 2021.
  4. ^ "Archive copy" (PDF). Archived (PDF) from the original on 2021-11-05. Retrieved 2021-02-18.{{cite web}}: CS1 maint: archived copy as title (link)
  5. ^ a b c d "DailyMed - ALMOTRIPTAN MALATE- almotriptan tablet, film coated". dailymed.nlm.nih.gov. Archived from the original on 22 March 2021. Retrieved 14 January 2022.
  6. ^ a b "Almotriptan Monograph for Professionals". Drugs.com. Archived from the original on 23 January 2021. Retrieved 14 January 2022.
  7. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 531. ISBN 9783527607495. Archived from the original on 2020-10-23. Retrieved 2021-02-18.
  8. ^ "Almotriptan Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 14 June 2016. Retrieved 14 January 2022.
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