User:Mr. Ibrahem/Aclidinium

Mr. Ibrahem/Aclidinium
Clinical data
Trade names	Bretaris Genuair, Eklira Genuair, Tudorza Pressair
Other names	Aclidinium bromide
AHFS/Drugs.com	Monograph
License data	US DailyMed: Aclidinium; US FDA: Aclidinium;
Routes of; administration	Inhalation
Drug class	Long-acting muscarinic antagonist (LAMA)
Legal status
Legal status	US: ℞-only; EU: Rx-only;
Pharmacokinetic data
Bioavailability	<5% (in system); 30% (in lung)
Metabolism	Ester hydrolysis
Elimination half-life	2–3 hrs
Duration of action	>24 hrs
Excretion	65% urine, 33% faeces
Identifiers
	IUPAC name [(8R)-1-(3-Phenoxypropyl)-1-azoniabicyclo[2.2.2]octan-8-yl] 2-hydroxy-2,2-dithiophen-2-ylacetate bromide;
Chemical and physical data
Formula	C26H30BrNO4S2
Molar mass	564.55 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [Br-].O=C(O[C@@H]3C2CC[N+](CCCOc1ccccc1)(CC2)C3)C(O)(c4sccc4)c5sccc5;
	InChI InChI=1S/C26H30NO4S2.BrH/c28-25(26(29,23-9-4-17-32-23)24-10-5-18-33-24)31-22-19-27(14-11-20(22)12-15-27)13-6-16-30-21-7-2-1-3-8-21;/h1-5,7-10,17-18,20,22,29H,6,11-16,19H2;1H/q+1;/p-1/t20?,22-,27?;/m0./s1 ; Key:XLAKJQPTOJHYDR-QTQXQZBYSA-M ;
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Aclidinium is a medication used for maintenance treatment of chronic obstructive pulmonary disease (COPD).^[1] It may improve quality of life and prevent hospitalization; but does not affect the risk of death or the need for steroids.^[2] It is unclear if it differs from tiotropium or other medications in the LAMA class.^[2] It is used by a dry powder inhaler.^[1]

Common side effects include headache, cough, and inflammation of the nose and throat.^[1] Other side effects may include diarrhea, bronchospasm, and urinary retention.^[3]^[1] It is a long-acting muscarinic antagonist (LAMA).^[1]

Aclidinium was approved for medical use in the United States in 2012.^[1] In the United Kingdom a month costs the NHS about 33 pounds.^[3] In the United States this amount costs about 560 USD as of 2021.^[4] It is also available together with formoterol.^[3]

References edit

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Aclidinium Monograph for Professionals". Drugs.com. Archived from the original on 21 January 2021. Retrieved 15 July 2021.
^ ^a ^b Ni, H; Soe, Z; Moe, S (2014). "Aclidinium bromide for stable chronic obstructive pulmonary disease". The Cochrane Database of Systematic Reviews (9): CD010509. doi:10.1002/14651858.CD010509.pub2. PMID 25234126.
^ ^a ^b ^c BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 260. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
^ "Aclidinium Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 15 July 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Aclidinium Monograph for Professionals". Drugs.com. Archived from the original on 21 January 2021. Retrieved 15 July 2021.

[Cochrane2014-2] Ni, H; Soe, Z; Moe, S (2014). "Aclidinium bromide for stable chronic obstructive pulmonary disease". The Cochrane Database of Systematic Reviews (9): CD010509. doi:10.1002/14651858.CD010509.pub2. PMID 25234126.

[BNF80-3] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 260. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[Gx2021-4] "Aclidinium Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 15 July 2021.

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