KIAA0895 is a human gene that codes for a protein known as KIAA0895 protein or hypothetical protein LOC23366.[1] Other known aliases are OTTHUMP00000206979 and OTTHUMP00000206980.[2]
Gene
editThe KIAA0895 gene is located at p14.2 on chromosome 7.
It can be transcribed into 15 different transcript variants, which in turn can produce 13 different isoforms of the protein.[3]
The genomic DNA is 65,976 [base pair]s long [1], while the longest mRNA that it produces is 4463 bases long.
Gene Neighborhood
editKIAA0895 is surrounded by the following genes on chromosome 7 [1]:
Protein
editThe longest protein isoform that is produced by the KIAA0895 gene is termed LOC23366 isoform 1 and is 520 amino acids long[4].
Regions
edit| Domain of unknown function 1704 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | DUF1704 | ||||||||
| Pfam | PF08014 | ||||||||
| InterPro | IPR012548 | ||||||||
| |||||||||
LOC23366 contains a domain of unknown function called DUF 1704 [5].
It also contains a region of low complexity from position 120 to position 150 in the protein[6], and an arginine-rich area from position 12 to position 51[7].
Post-translational Modification
editThe KIAA0895 protein is predicted to undergo phosphorylation at several serines, threonines, and tyrosines throughout it's structure, particularly in the first half of the protein[8] The predicted phosphorylation sites are shown on the accompanying graph. There are also predicted to be three N-linked glycosylation sites[9].
Expression
editKIAA0895 is shown to be expressed at low levels in various tissues throughout the body. It is expressed most highly in the adrenal gland, the bone marrow, and the testis.[10]. It is also found in cancerous tissues, most highly in cervical tumors and bladder carcinoma.
Conservation
editKIAA0895 has one paralog in humans known as KIAA0895L [11]. Orthologs have been found in all mammals, and eukaryotes through T. thermophila[12]. The full list of organisms in which orthologs have been found is given below.
- Pan troglodytes
- Pongo abelii
- Macaca mulatta
- Callithrix jacchus
- Sus scrofa
- Canis familiaris
- Ailuropoda melanoleuca
- Equus caballus
- Oryctolagus cuniculus
- Mus musculus
- Rattus norvegicus
- Monodelphis domestica
- Ornithorhynchus anatinus
- Taeniopygia guttata
- Meleagris gallopavo
- Gallus gallus
- Xenopus (Silurana) tropicalis
- Danio rerio
- Ciona intestinalis
- Strongylocentrotus purpuratus
- Branchiostoma floridae
- Tetrahymena thermophila
References
edit- ^ a b c "Entrez Gene: KIAA0895". Retrieved 4-24-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "GeneCards: KIAA0895 Gene". Retrieved 4-24-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "NCBI AceView: KIAA0895". Retrieved 4-24-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "NCBI Protein: LOC23366 isoform 1". Retrieved 5-9-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "Wellcome Trust Sanger Institute, Pfam". Retrieved 5-9-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "MyHits Dotlet". Retrieved 5-9-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "Uniprot". Retrieved 5-9-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "DTU Center for Biological Sciences, NetPhos". Retrieved 5-9-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "DTU Center for Biological Sciences, NetNGlyc". Retrieved 5-9-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "NCBI Unigene EST Profile: KIAA0895". Retrieved 5-9-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "KEGG: KIAA0895". Retrieved 5-9-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "NCBI BLAST". Retrieved 5-9-2011.
{{cite web}}: Check date values in:|accessdate=(help)