Evolutionary Considerations edit
Because Hypothyroidism is considered an iodine deficiency disorder, much research on the vulnerability to the disease focuses on the potential causes of this deficiency. Iodine intake directly affects the levels of the thyroid hormone, Triiodothyronine (T3), which is dependent on carbohydrate intake. The modern Western human diet is higher in carbohydrates than the Paleolithic diet, which leads to an increase in T3 levels. This means the iodine intake levels required in the diet should also increase for the thyroid to continue functioning properly. When a mismatch between the required iodine intake and actual intake occurs, it creates a vulnerability to Hypothyroidism.[1]
129.22.1.19 (talk) 08:12, 9 December 2013 (UTC)Lek39