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User:Lange.lea/Grete Kellenberger-Gujer

< User:Lange.lea
Grete Kellenberger-Gujer
Born(1919-11-12)November 12, 1919
Rümlang, Zürich, Switzerland
DiedMarch 13, 2011(2011-03-13) (aged 91)
Bülach, Switzerland
NationalitySwiss
AwardsNessim-Habif Prize, 1979

Grete Kellenberger-Gujer was a Swiss molecular biologist known for her discoveries in genetic recombination and restriction modification system of DNA. She was a pioneer in the genetic analysis of bacteriophages and contributed to the early development of molecular biology.[1][2]

Biography edit

After earning her matura in classics at the Töchterschule in Zürich, Grete Gujer studied chemistry at the Swiss Federal Institute of Technology in Zurich. There, she met Eduard Kellenberger, a physics student. The couple married in 1945. In 1946 they moved to Geneva, where Eduard Kellenberger began writing a thesis under Jean Weigle, professor of physics at the University of Geneva. Grete Kellenberger contributed to the development of new methods of preparing and analyzing biological samples using an electron microscope, a new technique at the time.[3][4][5] After Jean Weigle left for the California Institute of Technology in 1948, Grete Kellenberger took on an increased role in the study of lambda phage and its mutations at the University of Geneva. Her collaboration with Jean Weigle, who returned to Geneva every summer, is demonstrated their by regular correspondence archived at Caltech[6] and by numerous publications.[7][8][9][10][11]

It was Grete Kellenberger who gave Werner Arber, who completed a doctorate between 1954 and 1958, the conceptual basis and practices for his future studies in the genetics of bacteriophages.[12] Grete Kellenberger published several articles with Arber between 1957 and 1966.[13][14][15]

Grete Kellenberger's major scientific contribution was the discovery showing that recombination is due to a physical exchange of DNA and not selective replication.[11] An article on this subject authored by Grete Kellenberger, Maria Ludovica Zichichi, and Jean Weigle was published in the same issue of the Proceedings of the National Academy of Sciences (PNAS) as the article from Meselson and Weigle on the topic.[16] Maria Ludovica Zichichi worked with Grete Kellenberger from 1960 to 1962, and their collaboration resulted in five publications.[17][10][11][18][19]

In 1965, Grete Kellenberger, her husband Eduard Kellenberger, and members of their research team left for Manhattan, Kansas for a sabbatical year.[20] At Kansas State University, she worked closely with Ulrich Laemmli on phage T4. During this year, Eduard Kellenberger returned to Switzerland without his wife, and they divorced in 1967. Grete Kellenberger-Gujer continued to work in Kansas and later accepted a position as an independent researcher in a lab run by Lucien Caro at the Oak Ridge National Laboratory in Tennessee. In 1971, she returned to Geneva and worked in Lucien Caro's lab in the Department of Molecular Biology until her retirement in 1980. From 1971-1975, she worked with Douglas Berg, with whom she shared an interest in genetic analysis of bacteriophages and lambda plasmid dv. She published three articles with Berg.[21][22][23]

Awards and recognition edit

In 1979, the Faculty of Medicine at the University of Geneva awarded Grete Kellenberger-Gujer with the Nessim-Habif Prize.

 
Seminar Room Department Molecular Biology (veiled canvases)

In 2009, three portraits of Grete Kellenberger-Gujer were created by the Roger Pfund studio and displayed as part of an exhibit commemorating representative individuals from the University of Geneva as part of the university's 450th anniversary.[24] The portraits now hang in the university's Department of Molecular Biology seminar room across from a portrait of Werner Arber.

References edit

  1. ^ Citi, Sandra; Berg, Douglas E. "Grete Kellenberger-Gujer: Molecular biology research pioneer". Bacteriophage. 6 (2): 1–12. doi:10.1080/21597081.2016.1173168.
  2. ^ Gottesman, Max E.; Weisberg, Robert A. (2004-12-01). "Little Lambda, Who Made Thee?". Microbiology and Molecular Biology Reviews. 68 (4): 796–813. doi:10.1128/MMBR.68.4.796-813.2004. ISSN 1092-2172. PMC 539004. PMID 15590784.
  3. ^ Kellenberger, G.; Kellenberger, E. (1952-01-01). "[Bacteriolysis of a strain of bacillus cereus; evidence in electronic microscopy]". Schweizerische Zeitschrift Für Pathologie Und Bakteriologie. Revue Suisse De Pathologie Et De Bactériologie. 15 (2): 224–233. PMID 14950156.
  4. ^ E, KELLENBERGER; G, KELLENBERGER (1955-12-01). "[Study of colicinogenic strains by electron microscopy.]". Schweizerische Zeitschrift fur Pathologie und Bakteriologie. Revue suisse de pathologie et de bacteriologie. 19 (5).
  5. ^ Kellenberger, Grete; Kellenberger, Edouard (1957-04-01). "Electron microscopical studies of phage multiplication". Virology. 3 (2): 275–285. doi:10.1016/0042-6822(57)90093-4.
  6. ^ "Jean Jacques Weigle, 1901-1968, Physicist, Biologist". The Caltech Archives. Retrieved 2016-07-18.
  7. ^ Sloan, Phillip R. (2008-09-01). "Bruno J. Strasser. La fabrique d'une nouvelle science: La biologie moléculaire à l'âge atomique (1945–1964)". Isis. 99 (3): 660–661. doi:10.1086/593279. ISSN 0021-1753. {{cite journal}}: no-break space character in |first= at position 8 (help)
  8. ^ Arber, Werner; Kellenberger, Grete (1958-06-01). "Study of the properties of seven defective-lysogenic strains derived from Escherichia coli K12 (λ)". Virology. 5 (3): 458–475. doi:10.1016/0042-6822(58)90039-4.
  9. ^ Arber, W.; Kellenberger, G.; Weigle, J. "La défectuosité du phage lambda transducteur". Pathobiology. 20 (5): 659–665. doi:10.1159/000160176.
  10. ^ a b Kellenberger, G.; Zichichi, M. L.; Weigle, J. (1961-08-01). "A mutation affecting the DNA content of bacteriophage lambda and its lysogenizing properties". Journal of Molecular Biology. 3: 399–408. ISSN 0022-2836. PMID 13752286.
  11. ^ a b c Kellenberger, Grete, M. L. Zichichi, and J. J. Weigle. "Exchange of DNA in the recombination of bacteriophage λ." Proceedings of the National Academy of Sciences 47.6 (1961): 869-878.
  12. ^ Strasser, Bruno J (2006-01-01). La fabrique d'une nouvelle science la biologie moléculaire à l'âge atomique (1945-1964) (in French). Firenze: Leo S. Olschki. ISBN 9788822254962.
  13. ^ Arber, Werner; Kellenberger, Grete (1958-06-01). "Study of the properties of seven defective-lysogenic strains derived from Escherichia coli K12 (λ)". Virology. 5 (3): 458–475. doi:10.1016/0042-6822(58)90039-4.
  14. ^ Kellenberger, E.; Arber, W. (1955-12-01). "Die Struktur des Schwanzes der Phagen T2 und T4 und der Mechanismus der irreversiblen Adsorption". Zeitschrift für Naturforschung B. 10 (12). doi:10.1515/znb-1955-1206. ISSN 1865-7117.
  15. ^ Kellenberger, G.; Arber, W.; Kellenberger, E. (1959-10-01). "Eigenschaften uv-bestrahlter λ-Phagen". Zeitschrift für Naturforschung B. 14 (10). doi:10.1515/znb-1959-1001. ISSN 1865-7117.
  16. ^ Meselson, M.; Weigle, J. J. (1961-06-15). "Chromosome brekage accompanying genetic recombination in bacteriophage". Proceedings of the National Academy of Sciences of the United States of America. 47: 857–868. ISSN 0027-8424. PMC 221352. PMID 13769766.
  17. ^ Kellenberger, G., Zichichi, M. L., & Weigle, J. (1960). Mutations affecting the density of bacteriophage?. Nature, 187, 161-62.
  18. ^ Kellenberger, G.; Zichichi, M. L.; Epstein, H. T. (1962-05-01). "Heterozygosis and recombination of bacteriophage". Virology. 17: 44–55. ISSN 0042-6822. PMID 14454932.
  19. ^ Zichichi, M. L.; Kellenberger, G. (1963-04-01). "Two distinct functions in the lysogenization process: the repression of phage multiplication and incorporation of the prophage in the bacterial genome". Virology. 19: 450–460. ISSN 0042-6822. PMID 14003601.
  20. ^ Eisenstark, Abraham (2014-07-01). "Life in Science: Abraham Eisenstark". Bacteriophage. 4 (3): e29009. doi:10.4161/bact.29009. PMC 4116385. PMID 25101215.
  21. ^ Kellenberger-Gujer, G.; Boy de la Tour, E.; Berg, D. E. (1974-04-01). "Transfer of the lambda dv plasmid to new bacterial hosts". Virology. 58 (2): 576–585. ISSN 0042-6822. PMID 4595156.
  22. ^ Berg, D. E.; Kellenberger-Gujer, G. (1974-11-01). "N protein causes the lambda dv plasmid to inhibit heteroimmune phage lambda imm434 growth and stimulates lambda dv replication". Virology. 62 (1): 234–241. ISSN 0042-6822. PMID 4608877.
  23. ^ Berg, D., Kellenberger. G, & Caro, L. (1974, January). Regulation of lambda dv plasmid replication. In Experientia (Vol. 30, No. 6, pp. 699-699). Basel, Switzerland: Birkhauser Verlag.
  24. ^ Brigitte Mantilleri, Faces à faces 06/9. Exposition Uni Dufour, Genève, Université de Genève et Atelier Roger Pfund, 2009, 179 p., p. 143.


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