The Guillermo M. Luz is an Associate Director at Ayala Corporation, the holding company of one of the oldest and largest business groups in the Philippines, with business activities in property development, banking and financial services, telecommunications, water infrastructure development and management, automotive dealership and distribution, business process outsourcing, electronics manufacturing solutions, and new investments in power and renewable energy, infrastructure, health, and education.

He is also the Chief Resilience Officer and an Advisor of the Philippine Disaster Resilience Foundation (PDRF), the country's major private sector coordinator for disaster risk reduction management.

He was the Lead Coordinator for the Private Sector of the APEC National Organizing Council (APEC-NOC), the government agency in charge of preparations for the Philippines’ Chairmanship of APEC in 2015. He also served as the Chief Operating Officer of the APEC 2015 CEO Summit Host Committee.

Prior to his current posts, he was Executive Vice President and Chief Operating Officer of Ayala Foundation, Executive Director of the Makati Business Club, Managing Director of Knowledge Institute, and Secretary-General of NAMFREL.