User:Drummond7/DISC2

Disrupted in Schizophrenia 2 or DISC2 is a gene located on chromsome 1q42.^[1]. The gene was initially identified along with DISC1 in a large Scottish cohort with a t(1;11)(q42.1;q14.3) balanced segregation. Carriers of this familial chromosomal translocation are highly susceptible to the development of an array of psychiatric disorders, namely Schizophrenia, Major Depressive Disorder, and Bipolar Disorder.

References

^ Millar JK, Wilson-Annan JC, Anderson S, Christie S, Taylor MS, Semple CA, Devon RS, Clair DM, Muir WJ, Blackwood DH, Porteous DJ (May 2000). "Disruption of two novel genes by a translocation co-segregating with schizophrenia". Hum. Mol. Genet. 9 (9): 1415–23. doi:10.1093/hmg/9.9.1415. PMID 10814723.{{cite journal}}: CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link)

[pmid10814723-1] Millar JK, Wilson-Annan JC, Anderson S, Christie S, Taylor MS, Semple CA, Devon RS, Clair DM, Muir WJ, Blackwood DH, Porteous DJ (May 2000). "Disruption of two novel genes by a translocation co-segregating with schizophrenia". Hum. Mol. Genet. 9 (9): 1415–23. doi:10.1093/hmg/9.9.1415. PMID 10814723.{{cite journal}}: CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link)

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