Two ships of the United States Navy have been assigned the name USS Spruance, in honor of Admiral Raymond A. Spruance (1886–1969).
- USS Spruance (DD-963) was the lead ship of Spruance-class destroyers, launched in 1973 and struck in 2005.
- USS Spruance (DDG-111) is an Arleigh Burke-class destroyer, launched in 2010 and commissioned in 2011.
|This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.|