USS Guide is the name of the following ships of the U.S. Navy:
- USS Guide (AMc-83), was a coastal minesweeper launched 20 September 1941
- USS Guide (AM-447). was a minesweeper launched 17 April 1954
This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.