USP5

Ubiquitin specific peptidase 5 is an enzyme that in humans is encoded by the USP5 gene.

USP5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DAG, 2DAK, 2G43, 2G45, 3IHP
Identifiers
Aliases	USP5, ISOT, ubiquitin specific peptidase 5
External IDs	OMIM: 601447 MGI: 1347343 HomoloGene: 55758 GeneCards: USP5
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.31 Start 6,852,128 bp End 6,866,632 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 F2|6 59.17 cM Start 124,791,982 bp End 124,806,447 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex right adrenal gland Brodmann area 9 left adrenal gland gastrocnemius muscle stromal cell of endometrium cingulate gyrus right coronary artery skin of abdomen anterior pituitary Top expressed in spermatocyte superior frontal gyrus entorhinal cortex lip medulla oblongata cerebellar cortex yolk sac medial vestibular nucleus ventromedial nucleus paraventricular nucleus of hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity cysteine-type peptidase activity cysteine-type endopeptidase activity zinc ion binding ubiquitin binding protein binding hydrolase activity metal ion binding thiol-dependent deubiquitinase Cellular component lysosome cytosol Biological process protein K48-linked deubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process proteolysis protein deubiquitination protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8078 22225 Ensembl ENSG00000111667 ENSMUSG00000038429 UniProt P45974 P56399 RefSeq (mRNA) NM_001098536 NM_003481 NM_013700 NM_001326594 RefSeq (protein) NP_001092006 NP_003472 NP_001369517 NP_001369518 NP_001369519 NP_001369520 NP_001313523 NP_038728 Location (UCSC) Chr 12: 6.85 – 6.87 Mb Chr 6: 124.79 – 124.81 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

USP5 has been shown to interact with TADA3L.

Further reading

• D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Critical Reviews in Biochemistry and Molecular Biology. 33 (5): 337–52. doi:10.1080/10409239891204251. PMID 9827704.
• Falquet L, Paquet N, Frutiger S, Hughes GJ, Hoang-Van K, Jaton JC (Dec 1995). "cDNA cloning of a human 100 kDa de-ubiquitinating enzyme: the 100 kDa human de-ubiquitinase belongs to the ubiquitin C-terminal hydrolase family 2 (UCH2)". FEBS Letters. 376 (3): 233–7. doi:10.1016/0014-5793(95)01287-7. PMID 7498549. S2CID 19521632.
• Wilkinson KD, Tashayev VL, O'Connor LB, Larsen CN, Kasperek E, Pickart CM (Nov 1995). "Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T". Biochemistry. 34 (44): 14535–46. doi:10.1021/bi00044a032. PMID 7578059.
• Falquet L, Paquet N, Frutiger S, Hughes GJ, Hoang-Van K, Jaton JC (Feb 1995). "A human de-ubiquitinating enzyme with both isopeptidase and peptidase activities in vitro". FEBS Letters. 359 (1): 73–7. doi:10.1016/0014-5793(94)01451-6. PMID 7851534. S2CID 39667023.
• Ansari-Lari MA, Shen Y, Muzny DM, Lee W, Gibbs RA (Mar 1997). "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination". Genome Research. 7 (3): 268–80. doi:10.1101/gr.7.3.268. PMID 9074930.
• Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S (May 2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Research. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
• Engidawork E, Juranville JF, Fountoulakis M, Dierssen M, Lubec G (2001). "Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome". Protein Expression in Down Syndrome Brain. pp. 117–30. doi:10.1007/978-3-7091-6262-0_10. ISBN 978-3-211-83704-7. PMID 11771738. {{cite book}}: |journal= ignored (help)
• Gabriel JM, Lacombe T, Carobbio S, Paquet N, Bisig R, Cox JA, Jaton JC (Nov 2002). "Zinc is required for the catalytic activity of the human deubiquitinating isopeptidase T". Biochemistry. 41 (46): 13755–66. doi:10.1021/bi026096m. PMID 12427038.
• Lacombe T, Gabriel JM (Nov 2002). "Further characterization of the putative human isopeptidase T catalytic site". FEBS Letters. 531 (3): 469–74. doi:10.1016/S0014-5793(02)03586-X. PMID 12435595. S2CID 26832850.
• Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A (Apr 2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Molecular & Cellular Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Reyes-Turcu FE, Horton JR, Mullally JE, Heroux A, Cheng X, Wilkinson KD (Mar 2006). "The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin". Cell. 124 (6): 1197–208. doi:10.1016/j.cell.2006.02.038. PMID 16564012. S2CID 1312137.