UIC may refer to:
- UEFA Intertoto Cup, an association football tournament for member clubs of UEFA
- Uganda Insurance Commission
- UIC (band), a punk rock band from Canada whose moniker signifies "Unemployment Insurance Compensation" or "Underground in Canada"
- International Union of Railways, the French-language acronym for the "Union Internationale des Chemins de fer"
- Underwood International College, a department of Yonsei University
- Union of Islamic Courts, an armed group in Somalia, now called the "Supreme Islamic Courts Council"
- United International College, a liberal arts college in China
- The Unit Identification Code, an alphanumeric code used by the United States Department of Defense.
- University of Illinois at Chicago, a public four-year university in Chicago, Illinois
- Unified Image Codec, an Intel image format
- The Uranium Information Centre, a defunct website sponsored by uranium mining companies
- United Industrial Corporation Ltd, a Singapore property/real estate holding company
- User Identification Code, the user "number" in RSX-11 operating system.
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