Trafficking protein particle complex 6a

Trafficking protein particle complex 6A is a protein that in humans is encoded by the TRAPPC6A gene.

TRAPPC6A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2C0J, 2J3T
Identifiers
Aliases	TRAPPC6A, TRS33, trafficking protein particle complex 6A, trafficking protein particle complex subunit 6A
External IDs	OMIM: 610396; MGI: 1914341; HomoloGene: 69370; GeneCards: TRAPPC6A; OMA:TRAPPC6A - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.32 Start 45,162,928 bp End 45,178,237 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube skin of abdomen right lobe of liver left lobe of thyroid gland spleen right lobe of thyroid gland monocyte kidney body of stomach right adrenal gland n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytosol Golgi apparatus endoplasmic reticulum Golgi membrane cis-Golgi network trans-Golgi network TRAPP complex Biological process pigmentation COPII vesicle coating vesicle-mediated transport endoplasmic reticulum to Golgi vesicle-mediated transport melanosome assembly regulation of GTPase activity Golgi vesicle transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79090 67091 Ensembl ENSG00000007255 ENSMUSG00000002043 UniProt O75865 Q78XR0 RefSeq (mRNA) NM_024108 NM_001270891 NM_001270892 NM_001270893 NM_025960 RefSeq (protein) NP_001257820 NP_001257821 NP_001257822 NP_077013 NP_001257820.1 NP_001318110 NP_080236 Location (UCSC) Chr 19: 45.16 – 45.18 Mb n/a PubMed search
Wikidata
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Function

This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. Loss of expression of the related gene in mouse affects coat and eye pigmentation, suggesting that the encoded protein may be involved in melanosome biogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012].

Further reading

• Gwynn B, Smith RS, Rowe LB, Taylor BA, Peters LL (August 2006). "A mouse TRAPP-related protein is involved in pigmentation". Genomics. 88 (2): 196–203. doi:10.1016/j.ygeno.2006.04.002. PMID 16697553.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.