Thymosin beta-4, Y-chromosomal

Thymosin beta-4, Y-chromosomal is a protein that in humans is encoded by the TMSB4Y gene.

TMSB4Y
Identifiers
Aliases	TMSB4Y, TB4Y, thymosin beta 4, Y-linked, thymosin beta 4 Y-linked
External IDs	OMIM: 400017 GeneCards: TMSB4Y
Gene location (Human) Chr. Y chromosome (human) Band Yq11.221 Start 13,703,899 bp End 13,706,024 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum rectum Brodmann area 9 prostate ganglionic eminence putamen Achilles tendon hypothalamus nucleus accumbens prefrontal cortex n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding protein binding actin monomer binding Cellular component cytoskeleton cytoplasm nucleus cytosol Biological process sequestering of actin monomers regulation of actin polymerization or depolymerization actin filament organization regulation of cell migration osteoblast differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9087 n/a Ensembl ENSG00000154620 n/a UniProt O14604 n/a RefSeq (mRNA) NM_004202 n/a RefSeq (protein) NP_004193 n/a Location (UCSC) Chr Y: 13.7 – 13.71 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

The protein consists (in humans) of 44 amino acids (msdkpgmaei ekfdksklkk tetqeknpls sketieqerq ages) MolWt 4881.

Function

This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X (thymosin beta-4) escapes X inactivation and encodes an actin sequestering protein.

Further reading

• Yu FX, Lin SC, Morrison-Bogorad M, Atkinson MA, Yin HL (January 1993). "Thymosin beta 10 and thymosin beta 4 are both actin monomer sequestering proteins". The Journal of Biological Chemistry. 268 (1): 502–9. doi:10.1016/S0021-9258(18)54179-X. PMID 8416954.
• Li X, Zimmerman A, Copeland NG, Gilbert DJ, Jenkins NA, Yin HL (March 1996). "The mouse thymosin beta 4 gene: structure, promoter identification, and chromosome localization". Genomics. 32 (3): 388–94. doi:10.1006/geno.1996.0133. PMID 8838802.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC (June 2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. Bibcode:2003Natur.423..825S. doi:10.1038/nature01722. PMID 12815422.
• Torikai H, Akatsuka Y, Miyazaki M, Warren EH, Oba T, Tsujimura K, Motoyoshi K, Morishima Y, Kodera Y, Kuzushima K, Takahashi T (December 2004). "A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene". Journal of Immunology. 173 (11): 7046–54. doi:10.4049/jimmunol.173.11.7046. PMID 15557202.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.