Wikipedia

Tellurium ion resistance

The Tellurium Ion Resistance (TerC) Family (TC# 2.A.109) is part of the Lysine Exporter (LysE) Superfamily. A representative list of proteins belonging to the TerC family can be found in the Transporter Classification Database.[1]

TerC edit

The TerC family (Pfam 03741) includes the E. coli TerC protein (TC# 2.A.109.1.1) which has been implicated in tellurium resistance.[2] It is hypothesized to catalyze efflux of tellurium ions.[2][3] TerC is encoded by plasmid pTE53 from a clinical isolate of E. coli. It has 346 amino acyl residues (aas) and 9 putative transmembrane segments (TMSs) with a large hydrophilic loop between TMSs 5 and 6.[2]

A homologue in Arabidopsis thaliana (TC# 9.A.30.2.1) may function in prothylakoid membrane biogenises during early chloroplast development.[4] It has 384 aas and 7-8 putative TMSs. In E. coli, TerC forms a membrane complex with TerB as well as DctA, PspA, HslU, and RplK. The TerB/TerC complex may link different functional modules with biochemical activities of C4-dicarboxylate transport, inner membrane stress response (phage shock protein regulatory complex), ATPase/chaperone activity, and proteosynthesis.[5] It may be part of a metal sensing stress response system.[6] The co-presence of TerC and TerE but not TerF correlates with tellurite resistance when several hundred bacterial strains were assayed.[7]

Function edit

The reaction proposed to be catalyzed by TerC is:

tellurium ions (in) → tellurium ions (out).

See also edit

Further reading edit

  • Taylor, D. E. (1999). "Bacterial tellurite resistance". Trends in Microbiology. 7 (3): 111–115. doi:10.1016/s0966-842x(99)01454-7. PMID 10203839.
  • Kazanov, M.D.; Vitreschak, A.G.; Gelfand, M.S. (2007). "Abundance and functional diversity of riboswitches in microbial communities". BMC Genomics. 8: 347. doi:10.1186/1471-2164-8-347. PMC 2211319. PMID 17908319.
  • Kwon, K.C.; Cho, M.H. (2008). "Deletion of the chloroplast-localized AtTerC gene product in Arabidopsis thaliana leads to loss of the thylakoid membrane and to seedling lethality". Plant J. 55 (3): 428–442. doi:10.1111/j.1365-313X.2008.03523.x. PMID 18429937.
  • Meyer, M.M.; Hammond, M.C.; Salinas, Y.; Roth, A.; Sudarsan, N.; Breaker, R.R. (2011). "Challenges of ligand identification for riboswitch candidates". RNA Biol. 8 (1): 5–10. doi:10.4161/rna.8.1.13865. PMC 3142362. PMID 21317561.

References edit

  1. ^ "2.A.109 The Tellurium Ion Resistance (TerC) Family". Transporter Classification Database. Retrieved 2016-02-26.
  2. ^ a b c Burian, J.; Tu, N.; Kl'ucár, L.; Guller, L.; Lloyd-Jones, G.; Stuchlík, S.; Fejdi, P.; Siekel, P.; Turna, J. (1998-01-01). "In vivo and in vitro cloning and phenotype characterization of tellurite resistance determinant conferred by plasmid pTE53 of a clinical isolate of Escherichia coli". Folia Microbiologica. 43 (6): 589–599. doi:10.1007/bf02816374. ISSN 0015-5632. PMID 10069007. S2CID 44237747.
  3. ^ Kormutakova, R.; Klucar, L.; Turna, J. (2000-06-01). "DNA sequence analysis of the tellurite-resistance determinant from clinical strain of Escherichia coli and identification of essential genes". BioMetals. 13 (2): 135–139. doi:10.1023/A:1009272122989. ISSN 0966-0844. PMID 11016400. S2CID 22672098.
  4. ^ Kwon, Kwang-Chul; Cho, Myeon Haeng (2008-08-01). "Deletion of the chloroplast-localized AtTerC gene product in Arabidopsis thaliana leads to loss of the thylakoid membrane and to seedling lethality". The Plant Journal. 55 (3): 428–442. doi:10.1111/j.1365-313X.2008.03523.x. ISSN 1365-313X. PMID 18429937.
  5. ^ Turkovicova, L.; Smidak, R.; Jung, G.; Turna, J.; Lubec, G.; Aradska, J. (2016-01-09). "Proteomic analysis of the TerC interactome: Novel links to tellurite resistance and pathogenicity". Journal of Proteomics. 136: 167–73. doi:10.1016/j.jprot.2016.01.003. ISSN 1876-7737. PMID 26778143.
  6. ^ Anantharaman, Vivek; Iyer, Lakshminarayan M.; Aravind, L. (2012-10-30). "Ter-dependent stress response systems: novel pathways related to metal sensing, production of a nucleoside-like metabolite, and DNA-processing". Molecular BioSystems. 8 (12): 3142–3165. doi:10.1039/c2mb25239b. ISSN 1742-2051. PMC 4104200. PMID 23044854.
  7. ^ Orth, Dorothea; Grif, Katharina; Dierich, Manfred P.; Würzner, Reinhard (2007-03-01). "Variability in tellurite resistance and the ter gene cluster among Shiga toxin-producing Escherichia coli isolated from humans, animals and food". Research in Microbiology. 158 (2): 105–111. doi:10.1016/j.resmic.2006.10.007. ISSN 0923-2508. PMID 17317110.


 

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