Tectonin beta-propeller repeat containing 1

Tectonin beta-propeller repeat containing 1 is a protein that in humans is encoded by the TECPR1 gene.

TECPR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4TQ1
Identifiers
Aliases	TECPR1, tectonin beta-propeller repeat containing 1
External IDs	OMIM: 614781 MGI: 1917631 HomoloGene: 9120 GeneCards: TECPR1
Gene location (Human) Chr. Chromosome 7 (human) Band 7q21.3 Start 98,214,624 bp End 98,252,232 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 G2 Start 144,131,260 bp End 144,160,433 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland pancreatic ductal cell endothelial cell sural nerve trachea middle temporal gyrus prefrontal cortex tibialis anterior muscle blood appendix Top expressed in lacrimal gland cerebellar cortex internal carotid artery iris motor neuron thymus substantia nigra external carotid artery adrenal gland interventricular septum More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding phosphatidylinositol-3-phosphate binding lipid binding Cellular component integral component of membrane lysosomal membrane autophagosome membrane lysosome cytoplasmic vesicle membrane nucleoplasm intracellular membrane-bounded organelle Biological process autophagy autophagosome maturation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25851 70381 Ensembl ENSG00000205356 ENSMUSG00000066621 UniProt Q7Z6L1 Q80VP0 RefSeq (mRNA) NM_015395 NM_027410 NM_001356992 NM_001356993 RefSeq (protein) NP_056210 NP_081686 NP_001343921 NP_001343922 Location (UCSC) Chr 7: 98.21 – 98.25 Mb Chr 5: 144.13 – 144.16 Mb PubMed search
Wikidata
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Function

This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.