Talk:RHEB

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Mpotes12.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 07:39, 17 January 2022 (UTC)

Possible Citations for RHEB

Hello All, I would like to edit the RHEB wikipedia page and have found several articles that I believe are credible sources. Any feedback on them would be greatly appreciated. Thanks

Sato, Tatsuhiro; Akasu, Hitomi; Shimono, Wataru; Matsu, Chisa; Fujiwara, Yuki; Shibagaki, Yoshio; Heard, Jeffrey J.; Tamanoi, Fuyuhiko; Hattori, Seisuke (2015-01-09). "Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity". The Journal of Biological Chemistry 290 (2): 1096–1105. doi:10.1074/jbc.M114.592402. ISSN 1083-351X. PMC 4294477. PMID 25422319.

Jump up ^ Heard, Jeffrey J.; Fong, Valerie; Bathaie, S. Zahra; Tamanoi, Fuyuhiko (2014-09-01). "Recent progress in the study of the Rheb family GTPases". Cellular Signalling 26 (9): 1950–1957. doi:10.1016/j.cellsig.2014.05.011. ISSN 1873-3913. PMC 4134338. PMID 24863881.

Jump up ^ Zhang, Chao; Liu, Xiao-Ran; Cao, Yong-Chun; Tian, Jin-Ling; Zhen, Di; Luo, Xiao-Fei; Wang, Xin-Mei; Tian, Jian-Hui; Gao, Jian-Ming (2016-01-11). "Mammalian target of rapamycin/eukaryotic initiation factor 4F pathway regulates follicle growth and development of theca cells in mice". Reproduction, Fertility, and Development. doi:10.1071/RD15230. ISSN 1031-3613. PMID 26748416.

Jump up ^ Carroll, Bernadette; Maetzel, Dorothea; Maddocks, Oliver Dk; Otten, Gisela; Ratcliff, Matthew; Smith, Graham R.; Dunlop, Elaine A.; Passos, João F.; Davies, Owen R. (2016-01-07). "Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity". eLife 5. doi:10.7554/eLife.11058. ISSN 2050-084X. PMID 26742086.

Jump up ^ Hanker, A. B.; Mitin, N.; Wilder, R. S.; Henske, E. P.; Tamanoi, F.; Cox, A. D.; Der, C. J. (2010-01-21). "Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling". Oncogene 29 (3): 380–391. doi:10.1038/onc.2009.336. ISSN 1476-5594. PMC 2809798. PMID 19838215. — Preceding unsigned comment added by Mpotes12 (talk • contribs) 05:06, 2 February 2016 (UTC)

Outline for Article

Hello all, This is my proposed outline of the article. Any feedback will be greatly appreciated!

RHEB Description – as of right now, it is only one sentence long, but it is informative. I would like to add more sentences describing the proteins size in kDa and how long the polypeptide sequence is and importance in several intracellular pathways (namely mTOR and AMPK). 1. Structure a. This section doesn’t exist yet, and I would like to add a few paragraphs on the polypeptide sequence of RHEB. I have found several RHEB reviews that have very detailed descriptions of RHEB’s structure. b. Information like common motifs and preserved amino acids sequences (G-boxes and Switch areas) need to be added. c. Tertiary and Secondary structure of the protein needs to be more explained as well. d. Comparison to other RAS superfamily members can also be added and I have multiple sources that explicitly compare RHEB to other RAS superfamily proteins. 2. Function a. This section is currently a little brief, and I would like to add several functions that have been discovered more recently. These functions have been associated with the new interactions that have been published recently with CAD and AMPK. Also, RHEB’s function as a GTPase can be more explicitly explaines b. I want to add a picture and explain each domain of the protein, what is in each domain, and how each domain interacts with other proteins in the cell. 3. Interactions a. From what I have read, RHEB seems to interact with several more proteins than what is listed. b. It has recently been published that RHEB was discovered to interact with CAD and AMPK directly. 4. Mutations a. Several RHEB mutation have been studied and are a part of multiple studies on RHEB. I would like to add each mutation and discuss what is changed and how it changes function. 5. Pictures a. I would like to add several pictures that explain the RHEB proteins several motifs and its “G-box” so that it is easier to explain. b. I would also like to create some PYMOL pictures that show RHEB bounds to GTP and RHEB bound to GDP. — Preceding unsigned comment added by Mpotes12 (talk • contribs) 03:11, 9 February 2016 (UTC)