Talk:Puromycin

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Latest comment: 12 years ago4 comments4 people in discussion

If a molecule is lethal to both prokaryotes and eukaryotes, is it not better classified as a toxin rather than an antibiotic?

Perhaps it's lethal to eukaryotes through the mitochondria. This detail needs to be expanded. LostLucidity (talk) 19:01, 23 January 2008 (UTC)Reply

Puromycin is not lethal, it merely inhibits protein synthesis by terminating translation early. ArabburnvictiM (talk) 17:56, 31 March 2008 (UTC)Reply

Puromycin is very lethal in rats and humans causing irreversible renal nephrosis even in tiny amounts, see "Synthesis and antimicrobial activity of a carbocyclic puromycin analog. 6-Dimethylamino-9-[R-[2R-hydroxy-3R-(p-methoxyphenyl-L-alanylamino)]cyclopentyl]purine",Susan Daluge, Robert Vince,J. Med. Chem., 1972, 15 (2), pp 171–177 and other work by H. Nagasawa and Carl S. Alexander. Autumnfield (talk) 05:58, 2 April 2010 (UTC)Reply

Re: puromycin is lethal, it is listed as toxic (see http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241901/), although I have no doubt that it would be lethal at a high enough dose. Also puromycin, to my knowledge, does not cause the covalent linkage of the polypeptide chain to the mRNA molecule. Rather it is puromycin itself that gets covalently linked to the polypeptide. Microtubules (talk) 21:49, 23 April 2012 (UTC)Reply

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