Talk:Malignant hyperthermia

Untitled

I changed the object of "life-threatening" because it is not the trait itself that is dangerous, but the interaction with the anesthetic agents. Also, the incidence given is for events, not the presence of the trait. Osmodiar 11:18, 24 Nov 2004 (UTC)

hyperthermia

I added a description of the hypermetabolic state which comes between the initial release of calcium and the rhabdomyolisis. Hyperthermia is present about as frequently as rigidity, and its inclusion helps explain the name of this syndrome. Osmodiar 11:32, 24 Nov 2004 (UTC)

Tidying

Have done a bit o' tidying and added a couple of things. The references should should be linked to the bottom reference list and when I get a moment I might come back and do that. Turning into a nice article. Well done on the work so far.Mmoneypenny 20:21, 23 September 2006 (UTC)

Neuroleptic Malignant Syndrome

How about a line indicating the distinction from Neuroleptic Malignant Syndrome? They are sometimes confused.Mfbabcock (talk) 21:14, 16 March 2008 (UTC)

Presentation

Rigidity comes after hypermetabolic state. An episode detected by sky high end tidal CO2 can be aborted with treatment before any rigidity occurs. Mfbabcock 04:18, 28 December 2006 (UTC)

--> Please consider adding useful links for people who have MH.

North American Malignant Hyperthermia Registry https://www.mhreg.org/

MHAUS Official Website - Malignant Hyperthermia Association of the United States http://www.mhaus.org/index.cfm/fuseaction/Content.Display/PagePK/Home.cfm

Review

PMID 14661655 is a recent review. JFW | T@lk 10:39, 26 March 2008 (UTC)

Lots of edits!

Several different users have started contributing to this article. Fantastic. I have asked the latest one (Gqaggie (talk · contribs)) whether Huntl2 (talk · contribs) and Dpwkbw (talk · contribs) are in any way personally or otherwise related. JFW | T@lk 21:45, 26 March 2008 (UTC)

Some may be students of Badgettrg (talk · contribs) JFW | T@lk 11:42, 28 March 2008 (UTC)

Guideline

Shortest guideline I have ever seen: AAGBI guideline for UK is one page (more an aide memoire) - http://www.aagbi.org/publications/guidelines/docs/malignanthyp07amended.pdf JFW | T@lk 16:09, 26 May 2008 (UTC)

PMID 9093584 - slightly older review (probably outdated). JFW | T@lk 05:59, 23 July 2008 (UTC)

doi:10.1093/bja/aeq243 - European guideline, now 4 pages. JFW | T@lk 12:13, 26 September 2010 (UTC)

doi:10.1016/S0140-6736(98)03078-5 - 1998 Lancet seminar from Denborough. JFW | T@lk 12:40, 26 September 2010 (UTC)

Reviews

• Gurunluoglu R, Swanson JA, Haeck PC (2009). "Evidence-based patient safety advisory: malignant hyperthermia". Plast. Reconstr. Surg. 124 (4 Suppl): 68S–81S. doi:10.1097/PRS.0b013e3181b54626. PMID 20827241. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
• McAllen KJ, Schwartz DR (2010). "Adverse drug reactions resulting in hyperthermia in the intensive care unit". Crit. Care Med. 38 (6 Suppl): S244–52. doi:10.1097/CCM.0b013e3181dda0d4. PMID 20502177. {{cite journal}}: Unknown parameter |month= ignored (help)
• Stratman RC, Flynn JD, Hatton KW (2009). "Malignant hyperthermia: a pharmacogenetic disorder". Orthopedics. 32 (11): 835. doi:10.3928/01477447-20090922-18. PMID 19902883. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
• Klingler W, Rueffert H, Lehmann-Horn F, Girard T, Hopkins PM (2009). "Core myopathies and risk of malignant hyperthermia". Anesth. Analg. 109 (4): 1167–73. doi:10.1213/ANE.0b013e3181b5ae2d. PMID 19762745. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
• Wappler F (2010). "Anesthesia for patients with a history of malignant hyperthermia". Curr Opin Anaesthesiol. 23 (3): 417–22. doi:10.1097/ACO.0b013e328337ffe0. PMID 20173632. {{cite journal}}: Unknown parameter |month= ignored (help)
• Stowell KM (2008). "Malignant hyperthermia: a pharmacogenetic disorder". Pharmacogenomics. 9 (11): 1657–72. doi:10.2217/14622416.9.11.1657. PMID 19018722. {{cite journal}}: Unknown parameter |month= ignored (help)
• Brandom BW (2006). "Genetics of malignant hyperthermia". ScientificWorldJournal. 6: 1722–30. doi:10.1100/tsw.2006.289. PMID 17195870.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Rosenberg H, Davis M, James D, Pollock N, Stowell K (2007). "Malignant hyperthermia". Orphanet J Rare Dis. 2: 21. doi:10.1186/1750-1172-2-21. PMC 1867813. PMID 17456235.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)

Doc James (talk · contribs · email) 04:17, 22 October 2010 (UTC)

PMID 20179962 looks like it's not too bad. JFW | T@lk 14:28, 22 October 2010 (UTC)

New External Link?

I would like to add this external link to the MH page: http://pie.med.utoronto.ca/MH It's a good resource for clinicians and patients to learn about MH diagnosis and treatment, current research and has instructions for acute treatment and post-crisis treatment. The website was developed at Toronto General Hospital by the Malignant Hyperthermia Investigation Unit, so it is an authoritative source. Is this ok?

192.75.165.28 (talk) 21:23, 8 March 2011 (UTC)

antidepressants and MH

Can I ask what the source is for the statement that monoamine oxidase inhibitors are "suspected of causing MH?" My understanding is that MH is a symptom of serotonin syndrome(which, incidentally, should be mentioned in this article) — that is, it is not the MAOI per se that causes MH but the interaction of the MAOI with another serotonergic drug (such as an SSRI) — rather than a similar syndrome. I have never heard of MH being caused by an MAOI alone in normal clinical doses (although there have been cases reported in overdose of MAOIs alone, including moclobemide). Mia229 (talk) 01:41, 24 October 2012 (UTC)

I looked into this further...it seems that in some earlier diagnostic criteria for serotonin syndrome, the phrase "malignant hyperpyrexia" was used to refer to the similar symptoms such as the characteristic high fever. More recent criteria sets seem to have substituted "fever" (up to 40°C) but this might still be something to watch out for in older descriptions of serotonin syndrome. (The term "serotonin syndrome" is relatively new — for example, in 1984, when Libby Zion died from what is now recognised to have been serotonin syndrome, although the interaction was known (if, apparently, not to the residents who were treating Libby), the term was not yet in use. Not sure when if was coined or by whom, but I'm guessing it was sometime within a few years after the approval of fluoxetine (Prozac) in the USA. Mia229 (talk) 20:16, 4 January 2013 (UTC)

Misinformation

There was quite a bit of misinformation on this page so I have begun to correct much of it, including removing references to non-triggering agents that have been purported to cause MH (since disproven) and attempting to get rid of the myth that MH occurs postoperatively. Ron Litman Ronlitman (talk) 20:10, 15 October 2014 (UTC)

Ronlitman Thanks for agreeing to update this page, Dr Litman. Please ensure that you base your additions on high-quality secondary sources (see WP:MEDRS). Please let me know if I can be of any assistance. JFW | T@lk 17:01, 19 October 2014 (UTC)

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Pronoun, referent

I cannot imagine a referent for the first “Its” under Research, after animals. Maybe the animals came later. Anyway, a new subject should not begin by a pronoun. --Dominique Meeùs (talk) 10:56, 2 July 2017 (UTC)

Adjusted Doc James (talk · contribs · email) 16:09, 2 July 2017 (UTC)