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Latest comment: 4 years ago1 comment1 person in discussion
I got to this page because the article on Alfie Evans says that he had "an undiagnosed neurodegenerative disorder, later revealed to be GABA-transaminase deficiency." This article lets me know that GABA-transaminase refers to enzymes that "degrade the neurotransmitter GABA." The GABA article says that its "principal role is reducing neuronal excitability throughout the nervous system." So, Alfie Evans was lacking enzymes that help keep GABA in check and as a consequence there's too much GABA which means that neurons are not excitable enough? However, if you read on a bit further, it says this is mostly the case in "the adult vertebrate." However, if you don't stop there but read on, then you find out that things are completely different in the "neonatal" stage. "As the brain develops into adulthood, GABA's role changes from excitatory to inhibitory." So ALfie Evans' neurons were too excited? So, I don't know where the information should be, but if we're going to mention some medical condition, there ought to be a way for the reader to figure out what that is. Shouldn't there be? Ileanadu (talk) 01:03, 12 November 2019 (UTC)Reply
