Talk:Cocaine dependence

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I would like to expand to this page by adding a little more information as to how cocaine is a dopamine agonists and how it interacts with dopamine to create that initial "euphoric" high. Also, possibly briefly mention how the nucleus accumbens aids in the effects of reinforcement. I just thought a general overview would be helpful to those researching. My sources are http://www.macalester.edu/psychology/whathap/UBNRP/Dopamine/cocaine.html http://ac.els-cdn.com/S0896627300803748/1-s2.0-S0896627300803748-main.pdf?_tid=56d0f7a13c5b8aba03d6c84df7e7d976&acdnat=1339987694_1bcaa47cb4587463663dfe9d7b80590b --Haaammi (talk) 02:58, 18 June 2012 (UTC)Haaammi

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http://www.cocainewithdrawalsymptoms.net/ this website is highly suspect as it contains virtually no information and no verifiable sources. I would suggest you turn to http://www.nlm.nih.gov/medlineplus/ency/article/000947.htm instead, where it the established fact is clearly stated that cocaine withdrawal often does not have any physical component at all.

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— Preceding unsigned comment added by 85.234.194.104 (talk) 14:12, 10 October 2011 (UTC)

The section which refers to Aigner and Balster(1978) states that rhesus monkeys were neglectful of, violent towards, and in some cases actually ate their young, when dependent upon cocaine. No such observations are made by Aigner and Balster (1978), in whose study, the rhesus monkeys were housed individually, not with their young. 149.171.96.35 (talk) 05:38, 4 August 2008 (UTC)

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The bottom section has an inline reference to a Baylor U study, shouldn't this be annotated normally and not referenced in the article itself? Tnmonaghan (talk) 07:31, 19 January 2009 (UTC)

This was interesting on the talk page of cocaine: Talk:Cocaine#mesotelencephalic system. Nagelfar (talk) 01:15, 17 April 2009 (UTC)

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The presentation section until recently stated that race was a factor in the likelihood of a person developing a cocaine dependence. It seems quite suspect to me, and it was partly removed by another user. I was wondering if anyone knows of a source that could support the statement? Face-2-face (talk) 16:57, 8 May 2009 (UTC)

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The mortality in cocaine users is high

i propose the removal of this sentence if no plausible research is added.this is a vague sentence[high compared to what..certainly not heroin] and the risk of overdose when snorting cocaine is quite low ,again,compared to other drugs like amphetamines heroin etc on a personal note i might add that i know quite a few cocaine users and i have yet to see a fatality.i can't say the same compared to heroin —Preceding unsigned comment added by 79.117.12.207 (talk) 07:52, 21 June 2010 (UTC)

i realize this was posted two years ago, but it probably meant that it was high relative to the number of people who used like 20% of people who use cocaine might die of a heart attack and cocaine can be seen as contributing to the heart attack. should probably put that bit back. anyone against let me know, i still havent looked at the original text yet. — Preceding unsigned comment added by 98.15.165.150 (talk) 06:31, 24 April 2012 (UTC)

ADHD related cases

There are studies showing that some cases are ADHD related. The following are about a randomized double-blind trial using extended-release amphetamine, and in the second article they conclude that the ADHD symptoms precedes the cocaine use. ("This study suggests that when individuals show at least a 30% improvement in both ADHD and achieve cocaine abstinence, ADHD most commonly improves first.")

• Levin, Frances R.; Mariani, John J.; Specker, Sheila; Mooney, Marc; Mahony, Amy; Brooks, Daniel J.; Babb, David; Bai, Yun; Eberly, Lynn E.; Nunes, Edward V.; Grabowski, John (2015-06-01). "Extended-Release Mixed Amphetamine Salts vs Placebo for Comorbid Adult Attention-Deficit/Hyperactivity Disorder and Cocaine Use Disorder: A Randomized Clinical Trial". JAMA Psychiatry. 72 (6): 593. doi:10.1001/jamapsychiatry.2015.41. ISSN 2168-622X. PMC 4456227. PMID 25887096. S2CID 9894867. Retrieved 2023-07-26.

• Levin, Frances R.; Choi, C. Jean; Pavlicova, Martina; Mariani, John J.; Mahony, Amy; Brooks, Daniel J.; Nunes, Edward V.; Grabowski, John (July 2018). "How treatment improvement in ADHD and cocaine dependence are related to one another: A secondary analysis". Drug and Alcohol Dependence. 188: 135–140. doi:10.1016/j.drugalcdep.2018.03.043. PMC 6158788. PMID 29775957. S2CID 21736339.

And there is this review paper about different treatment for different cases:

• Brandt, Laura; Chao, Thomas; Comer, Sandra D.; Levin, Frances R. (April 2021). "Pharmacotherapeutic strategies for treating cocaine use disorder—what do we have to offer?". Addiction. 116 (4): 694–710. doi:10.1111/add.15242. ISSN 0965-2140. PMC 7930140. PMID 32888245. S2CID 221504341.

Maybe they could be useful for the article. — Arthurfragoso (talk) 20:30, 26 July 2023 (UTC)