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what happens if it gets a N-2-furyl-ethyl group (like Ro4-1539)? see http://en.wikipedia.org/wiki/Ro4-1539 —Preceding unsigned comment added by 77.8.78.168 (talk) 14:48, 16 November 2009 (UTC)
There's a lot of potentially abolishment: if the insertet Ethylene-group would be hydrated: see Dihydroetorphine. When the butyl-group gets one methyl longer or better substituted with isopentyl-group, it's get 3-fold stronger: see Oripavine. Your idea is good, but inserting on C-14 a phenylpropoxy-group boosts much more: see 14-Phenylpropoxymetopon (it's better to use metopon than morphine - or maybe it's better to use e Morphan-structure, beeing 7-fold stronger: compare N-Phenethylnormorphine with Phenomorphan. It should be possible to make a metopon-like derivat from morphan). Changing the phenyl-group to 2-furyl should also rises the strength a bit: see also Ro4-1539. Doing all this improvements, it should get an expectably power of 15.000-40.000x Morphine - the strongest possible opioid, I think.^^ =o) 77.176.145.110 (talk) 13:37, 5 September 2013 (UTC)