TRIM45

tripartite motif containing 45, also known as TRIM45, is a human gene.

TRIM45
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DS4
Identifiers
Aliases	TRIM45, RNF99, tripartite motif containing 45
External IDs	OMIM: 609318 MGI: 1918187 HomoloGene: 11865 GeneCards: TRIM45
Gene location (Human) Chr. Chromosome 1 (human) Band 1p13.1 Start 117,111,060 bp End 117,122,587 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F2.2 Start 100,829,518 bp End 100,844,236 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte right uterine tube gastrocnemius muscle tibialis anterior muscle deltoid muscle body of pancreas biceps brachii quadriceps femoris muscle vastus lateralis muscle thyroid gland Top expressed in otolith organ utricle olfactory epithelium seminiferous tubule internal carotid artery external carotid artery spermatid Jacobson's organ hand trigeminal ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding metal ion binding Cellular component intracellular anatomical structure nucleus nucleoplasm intercellular bridge cytoplasm cytosol Biological process bone development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80263 229644 Ensembl ENSG00000134253 ENSMUSG00000033233 UniProt Q9H8W5 Q6PFY8 RefSeq (mRNA) NM_001145635 NM_025188 NM_001165952 NM_001165953 NM_194343 RefSeq (protein) NP_001139107 NP_079464 NP_001159424 NP_001159425 NP_919324 Location (UCSC) Chr 1: 117.11 – 117.12 Mb Chr 3: 100.83 – 100.84 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the tripartite motif family. The encoded protein may function as a [transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.

Further reading

• Sardiello M, Cairo S, Fontanella B, Ballabio A, Meroni G (2008). "Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties". BMC Evolutionary Biology. 8 (1): 225. Bibcode:2008BMCEE...8..225S. doi:10.1186/1471-2148-8-225. PMC 2533329. PMID 18673550.
• Wang Y, Li Y, Qi X, Yuan W, Ai J, Zhu C, Cao L, Yang H, Liu F, Wu X, Liu M (Oct 2004). "TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1". Biochemical and Biophysical Research Communications. 323 (1): 9–16. doi:10.1016/j.bbrc.2004.08.048. PMID 15351693.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.