Tripartite motif-containing protein 16 is a protein that in humans is encoded by the TRIM16 gene .[4] [5]
This gene was identified as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing estrogen receptor. The protein encoded by this gene contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family.
The proteins of this family have been reported to be involved in a variety of biological processes including cell growth , differentiation and pathogenesis . Expression of this gene was detected in most tissues. Its function, however, has not yet been determined.[5]
References
edit
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047821 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments" . EMBO J . 20 (9): 2140–51. doi :10.1093/emboj/20.9.2140 . PMC 125245 PMID 11331580 . ^ a b "Entrez Gene: TRIM16 tripartite motif-containing 16" .
Further reading
edit
Liu HL, Golder-Novoselsky E, Seto MH, et al. (1999). "The novel estrogen-responsive B-box protein (EBBP) gene is tamoxifen-regulated in cells expressing an estrogen receptor DNA-binding domain mutant" . Mol. Endocrinol . 12 (11): 1733–48. doi :10.1210/mend.12.11.0193 PMID 9817599 . Beer HD, Munding C, Dubois N, et al. (2002). "The estrogen-responsive B box protein: a novel regulator of keratinocyte differentiation" . J. Biol. Chem . 277 (23): 20740–9. doi :10.1074/jbc.M111233200 hdl :20.500.11850/91604 PMID 11919186 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Munding C, Keller M, Niklaus G, et al. (2006). "The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion". Cell Death Differ . 13 (11): 1938–49. doi :10.1038/sj.cdd.4401896 . PMID 16575408 . S2CID 8953820 . Cheung BB, Bell J, Raif A, et al. (2006). "The estrogen-responsive B box protein is a novel regulator of the retinoid signal" . J. Biol. Chem . 281 (26): 18246–56. doi :10.1074/jbc.M600879200 PMID 16636064 .
