TINAG

Tubulointerstitial nephritis antigen is a protein that in humans is encoded by the TINAG gene.

TINAG
Identifiers
Aliases	TINAG, TIN-AG, tubulointerstitial nephritis antigen
External IDs	OMIM: 606749 MGI: 1349477 HomoloGene: 8082 GeneCards: TINAG
Gene location (Human) Chr. Chromosome 6 (human) Band 6p12.1 Start 54,307,859 bp End 54,390,142 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 D Start 76,858,975 bp End 76,953,076 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney rectum jejunal mucosa duodenum renal cortex gallbladder appendix renal medulla gastrocnemius muscle muscle tissue Top expressed in kidney Paneth cell left lung lobe left colon ileum intestinal villus jejunum duodenum right lung lobe crypt of lieberkuhn of small intestine More reference expression data BioGPS n/a
Gene ontology Molecular function scavenger receptor activity nucleotide binding cysteine-type endopeptidase activity polysaccharide binding cysteine-type peptidase activity Cellular component basement membrane extracellular region lysosome extracellular space Biological process cell adhesion proteolysis involved in cellular protein catabolic process receptor-mediated endocytosis immune response proteolysis vesicle-mediated transport endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27283 26944 Ensembl ENSG00000137251 ENSMUSG00000032357 UniProt Q9UJW2 n/a RefSeq (mRNA) NM_014464 NM_012033 RefSeq (protein) NP_055279 n/a Location (UCSC) Chr 6: 54.31 – 54.39 Mb Chr 9: 76.86 – 76.95 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

TINAG is a basement membrane glycoprotein initially identified as a target of antibodies in some forms of immunologically mediated tubulointerstitial nephritis.[supplied by OMIM]

Further reading

• Katz A, Fish AJ, Santamaria P, et al. (1993). "Role of antibodies to tubulointerstitial nephritis antigen in human anti-tubular basement membrane nephritis associated with membranous nephropathy". Am. J. Med. 93 (6): 691–8. doi:10.1016/0002-9343(92)90205-P. PMID 1466368.
• Butkowski RJ, Kleppel MM, Katz A, et al. (1992). "Distribution of tubulointerstitial nephritis antigen and evidence for multiple forms". Kidney Int. 40 (5): 838–46. doi:10.1038/ki.1991.283. PMID 1762287.
• Fliger FD, Wieslander J, Brentjens JR, et al. (1987). "Identification of a target antigen in human anti-tubular basement membrane nephritis". Kidney Int. 31 (3): 800–7. doi:10.1038/ki.1987.69. PMID 3553704.
• Chen Y, Krishnamurti U, Wayner EA, et al. (1996). "REceptors in proximal tubular epithelial cells for tubulointerstitial nephritis antigen". Kidney Int. 49 (1): 153–7. doi:10.1038/ki.1996.20. PMID 8770961.
• Nelson TR, Kim Y, Michael AF, et al. (1999). "Tubulointerstitial nephritis antigen (TIN-ag) is expressed in distinct segments of the developing human nephron". Connect. Tissue Res. 37 (1–2): 53–60. doi:10.3109/03008209809028899. PMID 9643646.
• Kim SH, Kaminker P, Campisi J (1999). "TIN2, a new regulator of telomere length in human cells". Nat. Genet. 23 (4): 405–12. doi:10.1038/70508. PMC 4940194. PMID 10581025.
• Zhou B, Nelson TR, Kashtan C, et al. (2000). "Identification of two alternatively spliced forms of human tubulointerstitial nephritis antigen (TIN-Ag)". J. Am. Soc. Nephrol. 11 (4): 658–68. doi:10.1681/ASN.V114658. PMID 10752525.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.