TEF (gene)

Thyrotroph embryonic factor is a protein that in humans is encoded by the TEF gene.

TEF
Identifiers
Aliases	TEF, PAR bZIP transcription factor, TEF transcription factor, PAR bZIP family member
External IDs	OMIM: 188595 MGI: 98663 HomoloGene: 31140 GeneCards: TEF
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.2 Start 41,367,333 bp End 41,399,326 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 E1|15 38.25 cM Start 81,686,622 bp End 81,711,064 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere nucleus accumbens external globus pallidus parietal lobe postcentral gyrus parotid gland caudate nucleus gastric mucosa putamen prefrontal cortex Top expressed in superior frontal gyrus entorhinal cortex olfactory tubercle cerebellar cortex ankle subiculum superior colliculus inferior colliculus primary motor cortex cerebellar vermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding double-stranded DNA binding protein binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II rhythmic process transcription by RNA polymerase II multicellular organism development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7008 21685 Ensembl ENSG00000167074 ENSMUSG00000022389 UniProt Q10587 Q9JLC6 RefSeq (mRNA) NM_003216 NM_001145398 NM_017376 NM_153484 RefSeq (protein) NP_001138870 NP_003207 NP_059072 NP_705617 Location (UCSC) Chr 22: 41.37 – 41.4 Mb Chr 15: 81.69 – 81.71 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Thyrotroph embryonic factor (TEF), a transcription factor, is a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter.

It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties.

Further reading

• Drolet DW, Scully KM, Simmons DM, et al. (1991). "TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins". Genes Dev. 5 (10): 1739–53. doi:10.1101/gad.5.10.1739. PMID 1916262.
• Hunger SP, Li S, Fall MZ, et al. (1996). "The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties". Blood. 87 (11): 4607–17. doi:10.1182/blood.V87.11.4607.bloodjournal87114607. PMID 8639829.
• Ossipow V, Fonjallaz P, Schibler U (1999). "An RNA Polymerase II Complex Containing All Essential Initiation Factors Binds to the Activation Domain of PAR Leucine Zipper Transcription Factor Thyroid Embryonic Factor". Mol. Cell. Biol. 19 (2): 1242–50. doi:10.1128/mcb.19.2.1242. PMC 116053. PMID 9891058.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Krueger DA, Warner EA, Dowd DR (2000). "Involvement of thyrotroph embryonic factor in calcium-mediated regulation of gene expression". J. Biol. Chem. 275 (19): 14524–31. doi:10.1074/jbc.275.19.14524. PMID 10799536.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Newman JR, Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays". Science. 300 (5628): 2097–101. Bibcode:2003Sci...300.2097N. doi:10.1126/science.1084648. PMID 12805554. S2CID 36715183.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.