Sup45p is the Saccharomyces cerevisiae (a yeast) eukaryotic translation termination factor. More specifically, it is the yeast eukaryotic release factor 1 (eRF1). Its job is to recognize stop codons in RNA and bind to them. It binds to the Sup35p protein and then takes on the shape of a tRNA molecule so that it can safety incorporate itself into the A site of the Ribosome to disruptits flow and "release" the protein and end translation.
- Paushkin, S. V.; Kushnirov, V. V.; Smirnov, V. N.; Ter-Avanesyan, M. D. (1997). "Interaction between yeast Sup45p (eRF1) and Sup35p (eRF3) polypeptide chain release factors: Implications for prion-dependent regulation". Molecular and cellular biology 17 (5): 2798–2805. PMC 232131. PMID 9111351.
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